Takata Yumie, King Irena B, Neuhouser Marian L, Schaffer Steve, Barnett Matt, Thornquist Mark, Peters Ulrike, Goodman Gary E
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North M4-B402, Seattle, WA 98109-1024, USA.
Cancer Causes Control. 2009 May;20(4):497-504. doi: 10.1007/s10552-009-9314-2. Epub 2009 Mar 3.
To examine the association between breast cancer risk and the fatty acid composition of phospholipids in prediagnostic serum samples.
We analyzed the fatty acid composition in 130 incident postmenopausal breast cancer cases and 257 matched controls nested within the beta-Carotene and Retinol Efficacy Trial Cohort. The fatty acid composition was measured by gas chromatography. Multivariate-adjusted odds ratios and corresponding 95% confidence intervals for the risk of breast cancer were estimated using logistic regression. Stratified analysis was conducted by smoking status.
There were no associations with breast cancer risk for total saturated, monounsaturated, n-3, n-6, or trans fatty acids among all women. For individual fatty acids, we observed an inverse association with the trans linoleic acid, 18:2n6tt (p(trend)=0.0002). Among current smokers, long-chain saturated fatty acids (22:0 and 24:0) and total 16:1 trans fatty acids were positively associated with the risk of breast cancer, whereas these fatty acids showed no association among former smokers.
Overall, we observed no significant association between serum phospholipid fatty acids and breast cancer risk, except for the trans linoleic acid isomer 18:2n6tt, which was unexpected. Our finding of a positive association of long-chain saturated fatty acids (22:0 and 24:0) and total 16:1 trans fatty acids with the risk of breast cancer only in current smokers may suggest an effect modification by smoking status. Our findings need to be replicated in future epidemiologic studies.
研究乳腺癌风险与诊断前血清样本中磷脂脂肪酸组成之间的关联。
我们分析了β-胡萝卜素和视黄醇功效试验队列中130例绝经后乳腺癌新发病例和257例匹配对照的脂肪酸组成。脂肪酸组成通过气相色谱法测定。使用逻辑回归估计乳腺癌风险的多变量调整比值比及相应的95%置信区间。按吸烟状况进行分层分析。
在所有女性中，总饱和脂肪酸、单不饱和脂肪酸、n-3脂肪酸、n-6脂肪酸或反式脂肪酸与乳腺癌风险均无关联。对于个别脂肪酸，我们观察到反式亚油酸18:2n6tt与乳腺癌风险呈负相关（p趋势=0.0002）。在当前吸烟者中，长链饱和脂肪酸（22:0和24:0）和总16:1反式脂肪酸与乳腺癌风险呈正相关，而在既往吸烟者中这些脂肪酸无关联。
总体而言，我们观察到血清磷脂脂肪酸与乳腺癌风险之间无显著关联，但反式亚油酸异构体18:2n6tt除外，这一结果出乎意料。我们发现长链饱和脂肪酸（22:0和24:0）和总16:1反式脂肪酸仅在当前吸烟者中与乳腺癌风险呈正相关，这可能提示吸烟状况对其有效应修饰作用。我们的研究结果需要在未来的流行病学研究中进行重复验证。
