Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, Calle 13 Sur 2901, Colonia Volcanes, C.P. 72420 Puebla, Puebla, Mexico.
Facultad de Nutrición, Benemérita Universidad Autónoma de Puebla, Calle 13 Sur 2901 Colonia Volcanes, C.P. 72420 Puebla, Puebla, Mexico.
Med Clin (Barc). 2021 Nov 12;157(9):409-417. doi: 10.1016/j.medcli.2020.07.026. Epub 2020 Oct 13.
Chronological age confers an increased risk for cardiovascular disease; however, chronological age does not reflect the subject's current health status. Therefore, we assessed whether Metabolic age (Met-age), based on free fat mass, is a predictor of cardiovascular risk (CVR).
Subjects attending either IMSS UMF-2 or CUSC-1 were asked to participate. CVR was assessed using the waist-to-height ratio (WHtR), whereas Met-age was determined using the TANITA bio-analyser (model: BC-545F Fitscan). The strengthen of association was determined by calculating Pearson's r and predictability was determined by the area-under-a-receiver-operating characteristic curve (AUC).
284 subjects participated in this study, of which 61.6% had increased CVR. As expected, the chronological age was significantly higher in the CVR(+) group than the CVR(-) group (47.3±14.4 v. 35.2±12.7, respectively, p<.001) as well as Met-age (59.3±15.5 v. 34.3±14.3, respectively, p<.001). There was a strong association between WHtR and Met-age (r=.720, p<.001) and a moderate association for chronological age (r=.407 p<.001); however, the correlation between WHtR and Met-age was significantly better than chronological age (Z=-5.91, p<.01). Met-age was a good predictor of CVR (AUC=.88, 95%CI: .83-.92, p<.001), whereas chronological age was a fair predictor (AUC=.72, 95%CI: .66-.78, p<.001). However, Met-age showed a higher discriminatory capacity for CVR than chronological age (z=-4.597, p<.001).
Here, we determined that Met-age correlated with a CVR index, WHtR, and was able to predict subjects with increased CVR better than chronological age.
年龄会增加心血管疾病的风险；然而，年龄并不能反映受试者的当前健康状况。因此，我们评估了基于游离脂肪量的代谢年龄（Met-age）是否是心血管风险（CVR）的预测因子。
邀请参加 IMSS UMF-2 或 CUSC-1 的受试者参加。使用腰高比（WHtR）评估 CVR，而 Met-age 则使用 TANITA 生物分析仪（型号：BC-545F Fitscan）确定。通过计算 Pearson r 来确定关联的强度，并通过受试者工作特征曲线下面积（AUC）来确定预测能力。
共有 284 名受试者参加了这项研究，其中 61.6%的受试者 CVR 增加。如预期的那样，CVR(+)组的年龄明显高于 CVR(-)组（分别为 47.3±14.4 岁和 35.2±12.7 岁，p<.001），以及 Met-age（分别为 59.3±15.5 岁和 34.3±14.3 岁，p<.001）。WHtR 与 Met-age 之间存在很强的相关性（r=.720，p<.001），与年龄的相关性适中（r=.407，p<.001）；然而，WHtR 与 Met-age 的相关性明显优于年龄（Z=-5.91，p<.01）。Met-age 是 CVR 的良好预测因子（AUC=.88，95%CI：.83-.92，p<.001），而年龄是一个适度的预测因子（AUC=.72，95%CI：.66-.78，p<.001）。然而，Met-age 对 CVR 的区分能力高于年龄（z=-4.597，p<.001）。
在这里，我们确定 Met-age 与 CVR 指数 WHtR 相关，并且能够比年龄更好地预测 CVR 增加的受试者。
