Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China.
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China.
Clin Immunol. 2020 Dec;221:108611. doi: 10.1016/j.clim.2020.108611. Epub 2020 Oct 14.
Since December 2019, Coronavirus Disease 2019 (COVID-19) has emerged as a global pandemic. We aimed to investigate the clinical characteristics and analyzed the risk factors for prolonged viral RNA shedding. We retrospectively collected data from 112 hospitalized COVID-19 patients in a single center in Wuhan, China. Factors associated with prolonged viral RNA shedding (≥28 days) were investigated. Forty-nine (43.8%) patients had prolonged viral RNA shedding. Patients with prolonged viral shedding were older and had a higher rate of hypertension. Proinflammatory cytokines, including interleukin-2R (IL-2R) and tumor necrosis factor-α (TNF-α), were significantly elevated in patients with prolonged viral shedding. Multivariate analysis revealed that hypertension, older age, lymphopenia and elevated serum IL-2R were independent risk factors for prolonged viral shedding. This comprehensive investigation revealed the distinct characteristics between patients with or without prolonged viral RNA shedding. Hypertension, older age, lymphopenia and high levels of proinflammatory cytokines may be correlated with prolonged viral shedding.
自 2019 年 12 月以来，2019 年冠状病毒病（COVID-19）已成为全球性大流行。本研究旨在调查 COVID-19 患者的临床特征，并分析病毒 RNA 持续排出的危险因素。我们回顾性收集了中国武汉一家中心 112 例住院 COVID-19 患者的数据。研究与病毒 RNA 持续排出（≥28 天）相关的因素。49 例（43.8%）患者的病毒 RNA 持续排出。病毒持续排出的患者年龄较大，且高血压发生率较高。病毒持续排出的患者促炎细胞因子，包括白细胞介素 2 受体（IL-2R）和肿瘤坏死因子-α（TNF-α）明显升高。多因素分析显示，高血压、年龄较大、淋巴细胞减少和血清 IL-2R 升高是病毒 RNA 持续排出的独立危险因素。这项综合研究揭示了具有或不具有病毒 RNA 持续排出的患者之间的明显特征。高血压、年龄较大、淋巴细胞减少和高水平的促炎细胞因子可能与病毒持续排出有关。
