Zhang G X, Carrillo-Vico A, Zhang W T, Gao S S, Izquierdo Ayuso G
Unidad de Esclerosis Múltiple. Servicio de Neurología. Hospital Vithas-Nisa, Sevilla, España; Instituto de Biomedicina de Sevilla, IBiS (Universidad de Sevilla, HUVR, Junta de Andalucía, CSIC) y Departamento de Bioquímica Médica y Biología Molecular e Inmunología, Universidad de Sevilla, Sevilla, España.
Instituto de Biomedicina de Sevilla, IBiS (Universidad de Sevilla, HUVR, Junta de Andalucía, CSIC) y Departamento de Bioquímica Médica y Biología Molecular e Inmunología, Universidad de Sevilla, Sevilla, España.
Neurologia (Engl Ed). 2020 Oct 14. doi: 10.1016/j.nrl.2020.07.022.
The prevalence of multiple sclerosis (MS) in Asian countries is thought to be lower than in Western countries, with Asian populations presenting 80% less risk of MS than white populations. Incidence and prevalence rates in Asian countries are therefore not well defined and their association with rates in neighboring countries, as well as with ethnic, environmental, and socioeconomic factors, are not well understood. We performed a comprehensive literature review of epidemiological data from China and neighbouring countries to study the frequency of the disease, focusing on prevalence, and the progression over time and the influence of sex-related, environmental, dietary, and sociocultural factors. Prevalence rates in China range between 0.88 cases/100,000 population in 1986 and 5.2 cases/100,000 population in 2013, with a non-significant upwards trend (p = .08). The increase observed in Japan, where figures ranged between 8.1 and 18.6 cases/100,000 population was highly significant (p < .001). Prevalence rates in countries with predominantly white populations are considerably higher and have increased over time, reaching 115 cases/100,000 population in 2015 (r = 0.79, p < .0001). In conclusion, the prevalence of MS in China appears to have risen in recent years, although Asian populations (including Chinese and Japanese populations, among others) appear to present less risk than other populations. Within Asia, geographical latitude appears not to be a determining factor for developing MS.
亚洲国家多发性硬化症（MS）的患病率被认为低于西方国家，亚洲人群患MS的风险比白人人群低80%。因此，亚洲国家的发病率和患病率尚未明确界定，人们也不太了解它们与邻国发病率以及种族、环境和社会经济因素之间的关系。我们对来自中国和邻国的流行病学数据进行了全面的文献综述，以研究该疾病的发病频率，重点关注患病率、随时间的进展以及性别相关、环境、饮食和社会文化因素的影响。中国的患病率在1986年为0.88例/10万人口，到2013年为5.2例/10万人口，呈不显著的上升趋势（p = 0.08）。在日本观察到的增长非常显著（p < 0.001），其数字在8.1至18.6例/10万人口之间。以白人为主的国家的患病率要高得多，且随时间有所增加，在2015年达到115例/10万人口（r = 0.79，p < 0.0001）。总之，近年来中国MS的患病率似乎有所上升，尽管亚洲人群（包括中国和日本人群等）似乎比其他人群患病风险更低。在亚洲范围内，地理纬度似乎不是患MS的决定性因素。
