Departments of Neurology, SUNY Downstate Health Sciences University, Brooklyn, NY, United States; Department of Neurology, Kings County Hospital Center, Brooklyn, NY, United States.
Departments of Neurology, SUNY Downstate Health Sciences University, Brooklyn, NY, United States; Department of Neurology, Kings County Hospital Center, Brooklyn, NY, United States.
J Clin Neurosci. 2020 Sep;79:275-276. doi: 10.1016/j.jocn.2020.07.033. Epub 2020 Jul 23.
Since the outbreak with novel corona virus in December 2019, a myriad of different neurological manifestations in patients with COVID-19 infection have been reported. We present a case of non-traumatic intracranial hemorrhage in the olfactory gyrus in a patient who tested positive for SARS-COV-2. The area of hemorrhage is not a common location for spontaneous hemorrhage. Given that loss of smell is considered a relatively common symptom of this pandemic, it is an intriguing association of COVID-19 and olfactory gyrus ICH for neurotropism of SARS-CoV2 for olfactory bulb and glia cells through nasal mucosa. Future studies will need to elucidate the exact mechanism of anosmia from COVID-19 and potential mechanisms leading to ICH.
自 2019 年 12 月新型冠状病毒爆发以来，已有大量关于 COVID-19 感染患者出现不同神经表现的报道。我们报告了一例 SARS-COV-2 检测阳性的患者发生非创伤性嗅脑回颅内出血。出血部位并非自发性出血的常见位置。鉴于嗅觉丧失被认为是这一流行疾病的相对常见症状，因此 COVID-19 与嗅脑回 ICH 的关联令人好奇，提示 SARS-CoV2 通过鼻黏膜对嗅球和神经胶质细胞具有神经嗜性。未来的研究需要阐明 COVID-19 导致嗅觉丧失的确切机制以及导致 ICH 的潜在机制。
