Key Laboratory of Public Health Safety of Ministry of Education, Collaborative Innovation Center of Social Risks Governance in Health, School of Public Health, Fudan University, Shanghai 200000, China.
Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai 200000, China.
Int J Environ Res Public Health. 2017 Jun 5;14(6):598. doi: 10.3390/ijerph14060598.
Phthalate exposure was reported to be associated with diabetes mellitus (DM) and cardiovascular disease (CVD). Yet, reported associations and the potential sex differences are inconsistent. We conducted a cross-sectional study involving 2330 participants in the Fall of 2012. Urinary metabolites of 10 phthalates were measured. The status of having DM and CVD-related outcomes were self-reported. In the overall study population, the logistic regression analyses showed that the urinary levels of mono-2-ethyl-5-oxohexyphthalate (MEOHP), mono-2-ethyl-5-hydroxyhexylphthalate(MEHHP) and mono-2-ethyl-5-carboxypentylphthalate (MECPP) were positively associated with DM. Higher urinary levels of monomethyl phthalate (MMP) and mono-2-carboxymethyl-hexyl phthalate (MCMHP) were associated with increased odds of hyperlipidemia, while mono-2-ethylhexylphthalate (MEHP) was significantly inverse-associated with hyperlipidemia. We did not observe significant associations for other CVD-related outcomes with phthalate metabolites. When stratifying by sex, MEHHP, MEOHP, MECPP, MCMHP and the micromolar sums of the oxidative metabolites of DEHP (ΣDEHP) were all significantly related to DM in males, but not in females. No significant sex differences were found in CVD-related outcomes, except the sporadic associations between phthalates and hyperlipidemia. These findings highlight the importance of investigating the sex-specific relationship between phthalates exposure and DM.
邻苯二甲酸酯暴露与糖尿病（DM）和心血管疾病（CVD）有关。然而，报告的相关性和潜在的性别差异并不一致。我们在 2012 年秋季进行了一项涉及 2330 名参与者的横断面研究。测量了 10 种邻苯二甲酸酯的尿代谢物。DM 和 CVD 相关结局的状况是自我报告的。在整个研究人群中，逻辑回归分析显示，单-2-乙基-5-氧代己基邻苯二甲酸酯（MEOHP）、单-2-乙基-5-羟基己基邻苯二甲酸酯（MEHHP）和单-2-乙基-5-羧基戊基邻苯二甲酸酯（MECPP）的尿水平与 DM 呈正相关。较高水平的单甲基邻苯二甲酸酯（MMP）和单-2-羧基甲基己基邻苯二甲酸酯（MCMHP）与血脂异常的几率增加相关，而邻苯二甲酸二（2-乙基己基）酯（DEHP）的单-2-乙基己基邻苯二甲酸酯（MEHP）则与血脂异常呈显著负相关。我们没有观察到其他与 CVD 相关的结局与邻苯二甲酸酯代谢物之间存在显著关联。当按性别分层时，MEHHP、MEOHP、MECPP、MCMHP 和 DEHP 的氧化代谢物的微摩尔总和（ΣDEHP）在男性中与 DM 均有显著相关性，但在女性中无显著相关性。除了邻苯二甲酸酯与血脂异常之间的偶发性关联外，在 CVD 相关结局方面没有发现显著的性别差异。这些发现强调了研究邻苯二甲酸酯暴露与 DM 之间的性别特异性关系的重要性。
