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Aloe vera gel and cesarean wound healing; a randomized controlled clinical trial.芦荟凝胶与剖宫产伤口愈合；一项随机对照临床试验
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Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies.特应性皮炎管理指南：第 2 节。特应性皮炎的局部治疗管理和治疗。
J Am Acad Dermatol. 2014 Jul;71(1):116-32. doi: 10.1016/j.jaad.2014.03.023. Epub 2014 May 9.
3
Efficacy of allergen-specific immunotherapy for atopic dermatitis: a systematic review and meta-analysis of randomized controlled trials.变应原特异性免疫疗法治疗特应性皮炎的疗效：系统评价和随机对照试验的荟萃分析。
J Allergy Clin Immunol. 2013 Jul;132(1):110-7. doi: 10.1016/j.jaci.2013.02.044. Epub 2013 May 3.
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The effect of aloe vera oral administration on cutaneous wound healing in type 2 diabetic rats.口服芦荟对2型糖尿病大鼠皮肤伤口愈合的影响。
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Influence of Aloe Vera gel on dermal wound healing process in rat.芦荟凝胶对大鼠皮肤创伤愈合过程的影响。
Toxicol Mech Methods. 2009 Jan;19(1):73-7. doi: 10.1080/15376510802442444.
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Clin Dermatol. 2009 Mar-Apr;27(2):159-65. doi: 10.1016/j.clindermatol.2008.01.008.
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Novel antibacterial and emollient effects of coconut and virgin olive oils in adult atopic dermatitis.椰子油和初榨橄榄油对成人特应性皮炎的新型抗菌和润肤作用。
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The efficacy of aloe vera used for burn wound healing: a systematic review.芦荟用于烧伤创面愈合的疗效：一项系统评价。
Burns. 2007 Sep;33(6):713-8. doi: 10.1016/j.burns.2006.10.384. Epub 2007 May 17.
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A systematic review of the safety of topical therapies for atopic dermatitis.对特应性皮炎局部治疗安全性的系统评价。
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A double-blind, placebo-controlled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris.一项关于市售芦荟凝胶治疗轻度至中度寻常型银屑病的双盲、安慰剂对照研究。
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比较[具体药物名称]与橄榄油复方乳膏和外用倍他米松治疗特应性皮炎的疗效：一项随机双盲临床试验。 （你提供的原文中“Comparing the Therapeutic Effects of and Olive Oil Combination Cream”这里少了具体药物名称）

Comparing the Therapeutic Effects of and Olive Oil Combination Cream versus Topical Betamethasone for Atopic Dermatitis: A Randomized Double-blind Clinical Trial.

作者信息

Panahi Yunes, Rastgar Nassim, Zamani Ali, Sahebkar Amirhossein

机构信息

Pharmacotherapy Department, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Department of Pharmaceutics, Faculty of Pharmacy, Pharmaceutical Science Branch, Islamic Azad University, Tehran, Iran.

出版信息

J Pharmacopuncture. 2020 Sep 30;23(3):173-178. doi: 10.3831/KPI.2020.23.3.173.

DOI:10.3831/KPI.2020.23.3.173
PMID:33072415
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7540232/
Abstract

OBJECTIVES

Atopic dermatitis (AD) is a prevalent and chronic, pruritic inflammatory skin condition that can influence all age groups. AD is associated with a poor health-related quality of life. This randomized clinical trial was performed to compare the effectiveness of Olivederma (combination of and virgin olive oil) or betamethasone regarding disease severity, quality of life, serum IgE and eosinophil count.

METHODS

Thirty-six AD patients were randomly allocated to topical Olivederma or betamethasone, and were followed for 6 weeks.

RESULTS

Total SCORAD severity scores showed significant decrease in both groups, while it was more prominent in Olivederma group (64.5% improvement in Olivederma vs. 13.5% improvement in Betamethasone, p-value < 0.001). Quality of life (DLQI questionnaire) of AD patients was significantly improved after 6 weeks treatment with Betamethasone (22.3%, p < 0.001) and Olivederma (60.7%, p-value < 0.001). Olivederma group showed a significantly lower DLQI score in comparison with Betamethasone treated patients after 6 weeks of therapy (p < 0.001). Improvements in eosinophil count and serum IgE was observed.

CONCLUSION

In summary, this study shows that Olivederma is superior to topical Betamethasone after 6 weeks of therapy with regard to disease severity, quality of life and eosinophil count.

摘要

目的

特应性皮炎（AD）是一种常见的慢性瘙痒性炎症性皮肤病，可影响所有年龄组。AD与健康相关生活质量较差有关。本随机临床试验旨在比较橄榄油乳膏（[成分]与初榨橄榄油的组合）或倍他米松在疾病严重程度、生活质量、血清IgE和嗜酸性粒细胞计数方面的疗效。

方法

36例AD患者被随机分配至外用橄榄油乳膏或倍他米松组，并随访6周。

结果

两组的总SCORAD严重程度评分均显著降低，而在橄榄油乳膏组更为显著（橄榄油乳膏组改善64.5%，倍他米松组改善13.5%，p值<0.001）。用倍他米松（22.3%，p<0.001）和橄榄油乳膏（60.7%，p值<0.001）治疗6周后，AD患者的生活质量（DLQI问卷）显著改善。治疗6周后，与倍他米松治疗的患者相比，橄榄油乳膏组的DLQI评分显著更低（p<0.001）。观察到嗜酸性粒细胞计数和血清IgE有所改善。

结论

总之，本研究表明，在治疗6周后，就疾病严重程度、生活质量和嗜酸性粒细胞计数而言，橄榄油乳膏优于外用倍他米松。