Dorooshi Gholamali, Zoofaghari Shafeajafar, Samsamshariat Shiva, Rahimi Alireza, Otroshi Arman
Department of Clinical Toxicology, Isfahan Clinical Toxicology Research Center, Khorshid Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Clinical Informationist Research Group, Health Information Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2020 Aug 28;9:40. doi: 10.4103/abr.abr_129_20. eCollection 2020.
Poisoning with any of the colchicine or chloroquine drugs is rare. These drugs exert therapeutic and toxic effects on tissues by different mechanisms. Colchicine is used to treat a number of rheumatologic diseases and heart problems. In addition, chloroquine is used to treat malaria and some inflammatory diseases. There is a small gap between the therapeutic and toxic doses of these drugs. Gastrointestinal symptoms are the initial causes of poisoning with these drugs and then widespread organ failure in later stages can lead to sudden cardiac death. We introduce a case of concurrent poisoning with both drugs, in which the patient presented with a headache, nausea, and vomiting several hours after suicide. On the 1 day, the patient's status was stable, but on the 2 day, the patient suddenly becomes ill and died even though the patient received supportive therapy. Concurrent poisoning with chloroquine and colchicine is extremely lethal, and early aggressive management is recommended even in an apparently stable patient.
秋水仙碱或氯喹类药物中毒均较为罕见。这些药物通过不同机制对组织产生治疗作用和毒性作用。秋水仙碱用于治疗多种风湿性疾病和心脏问题。此外，氯喹用于治疗疟疾和一些炎症性疾病。这些药物的治疗剂量和中毒剂量之间差距较小。胃肠道症状是这些药物中毒的初始原因，后期广泛的器官衰竭可导致心源性猝死。我们介绍一例同时服用这两种药物中毒的病例，该患者在自杀数小时后出现头痛、恶心和呕吐。第一天，患者情况稳定，但第二天，尽管接受了支持治疗，患者突然病情加重并死亡。氯喹和秋水仙碱同时中毒极具致死性，即使是看似稳定的患者也建议尽早积极治疗。
