Grosvenor T, Perrigin D M, Perrigin J, Maslovitz B
Am J Optom Physiol Opt. 1987 Jul;64(7):482-98.
In a randomized clinical trial designed to test the efficacy of bifocal lenses for the control of juvenile myopia, each of 207 children between the ages of 6 and 15 years wore single vision lenses, +1.00 D add bifocals, or +2.00 D add bifocals for a period of 3 years. For the 124 subjects who completed the study, the mean changes in refraction were found to be -0.34 D per year for subjects wearing single vision lenses, -0.36 D per year for those wearing +1.00 D add bifocals, and -0.34 D per year for those wearing +2.00 D add bifocals. These differences were not statistically significant. When subjects in all three treatment groups were combined, it was found that the rate of progression tended to be the most rapid for subjects who entered the study at an early age with a large amount of myopia, and tended to be the least rapid for subjects who entered the study at a later age with a small amount of myopia. It was also found that subjects having with-the-rule astigmatism progressed more slowly than those having no astigmatism or against-the-rule astigmatism.
在一项旨在测试双焦点镜片控制青少年近视疗效的随机临床试验中，207名6至15岁的儿童每人佩戴单焦点镜片、附加度数为+1.00 D的双焦点镜片或附加度数为+2.00 D的双焦点镜片，为期3年。对于完成研究的124名受试者，发现佩戴单焦点镜片的受试者每年的屈光度平均变化为-0.34 D，佩戴附加度数为+1.00 D双焦点镜片的受试者每年为-0.36 D，佩戴附加度数为+2.00 D双焦点镜片的受试者每年为-0.34 D。这些差异无统计学意义。当将所有三个治疗组的受试者合并时，发现对于那些在年轻时近视度数高就进入研究的受试者，进展速度往往最快，而对于那些在较晚年龄近视度数低才进入研究的受试者，进展速度往往最慢。还发现，顺规散光的受试者比无散光或逆规散光的受试者进展更慢。
