Section of Endocrinology and Investigative Medicine, Imperial College London, London, United Kingdom.
Department of Endocrinology, Imperial College Healthcare National Health Service (NHS) Trust, London, United Kingdom.
Front Endocrinol (Lausanne). 2022 Jun 9;13:928143. doi: 10.3389/fendo.2022.928143. eCollection 2022.
The neuropeptide kisspeptin is now well-established as the master regulator of the mammalian reproductive axis. Beyond the hypothalamus, kisspeptin and its cognate receptor are also extensively distributed in extra-hypothalamic brain regions. An expanding pool of animal and human data demonstrates that kisspeptin sits within an extensive neuroanatomical and functional framework through which it can integrate a range of internal and external cues with appropriate neuroendocrine and behavioural responses. In keeping with this, recent studies reveal wide-reaching effects of kisspeptin on key behaviours such as olfactory-mediated partner preference, sexual motivation, copulatory behaviour, bonding, mood, and emotions. In this review, we provide a comprehensive update on the current animal and human literature highlighting the far-reaching behaviour and mood-altering roles of kisspeptin. A comprehensive understanding of this important area in kisspeptin biology is key to the escalating development of kisspeptin-based therapies for common reproductive and related psychological and psychosexual disorders.
神经肽 kisspeptin 现已被充分确认为哺乳动物生殖轴的主要调节剂。除了下丘脑之外，kisspeptin 和其同源受体也广泛分布于下丘脑外的脑区。越来越多的动物和人类数据表明，kisspeptin 位于一个广泛的神经解剖和功能框架内，通过该框架，它可以将一系列内部和外部线索与适当的神经内分泌和行为反应整合在一起。与之相符的是，最近的研究揭示了 kisspeptin 对关键行为的广泛影响，如嗅觉介导的伴侣偏好、性动机、交配行为、结合、情绪和情感。在这篇综述中，我们提供了关于当前动物和人类文献的全面更新，强调了 kisspeptin 的广泛行为和情绪改变作用。全面了解 kisspeptin 生物学中的这一重要领域是基于 kisspeptin 的治疗方法不断发展的关键，这些方法可用于常见的生殖及相关心理和性心理障碍。
