Wu Shuqi, Li Yang, Zhang Ruofei, Fan Kelong, Ding Weihang, Xu Letong, Zhang Lianbing
School of Life Sciences, Key Laboratory of Space Bioscience & Biotechnology, Northwestern Polytechnical University, Xi'an, 710072, China.
CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China.
Talanta. 2021 Jan 1;221:121435. doi: 10.1016/j.talanta.2020.121435. Epub 2020 Jul 25.
Multifunctional nanocomposites that possess imaging and high-performance therapeutic features are experiencing a surge in interest in the precision clinical anticancer treatment. In this work, we reported the fabrication and bio-application of a novel persistent luminescence-polypyrrole nanocomposite (LPLNP@SPP) for photoacoustic/persistent luminescence (PA/PL) dual-modal imaging guided photothermal therapy (PTT). The construction of LPLNP@SPP avoids the PL quenching of LPLNP-OH by the polypyrrole-coating, and thus enables the combination of PL and PTT. The LPLNP@SPP shows excellent biocompatibility, long lasting near-infrared (NIR) PL emitting without in situ excitation and high-contrast PA signals. Meanwhile, this nanocomposite exhibits strong NIR absorbance and exceptional photothermal conversion capability, which provides notable potential for imaging-guided antitumor therapy. Thus, our work highlights the dual-functional core-shell LPLNP@SPP as a feasible theranostic nanoplatform for cancer diagnosis and therapy.
具有成像和高性能治疗特性的多功能纳米复合材料在精准临床抗癌治疗方面正受到越来越多的关注。在这项工作中，我们报道了一种新型的持久发光-聚吡咯纳米复合材料（LPLNP@SPP）用于光声/持久发光（PA/PL）双模态成像引导光热治疗（PTT）的制备及其生物应用。LPLNP@SPP的构建避免了聚吡咯涂层导致LPLNP-OH的PL猝灭，从而实现了PL和PTT的结合。LPLNP@SPP表现出优异的生物相容性、无需原位激发的持久近红外（NIR）PL发射以及高对比度的PA信号。同时，这种纳米复合材料表现出强烈的NIR吸收和出色的光热转换能力，为成像引导的抗肿瘤治疗提供了显著的潜力。因此，我们的工作突出了双功能核壳LPLNP@SPP作为一种可行的癌症诊断和治疗的诊疗纳米平台。
