Mohammed Jajere Saleh, Hassan Latiffah, Zakaria Zunita, Abu Jalila, Abdul Aziz Saleha
Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor 43400 UPM, Malaysia.
Antibiotics (Basel). 2020 Oct 15;9(10):701. doi: 10.3390/antibiotics9100701.
The emergence of multidrug resistance (MDR), including colistin resistance, among Enterobacteriaceae recovered from food animals poses a serious public health threat because of the potential transmission of these resistant variants to humans along the food chain. Village chickens or Ayam Kampung are free-range birds and are preferred by a growing number of consumers who consider these chickens to be organic and more wholesome. The current study investigates the antibiogram profiles of isolates recovered from village chicken flocks in South-central Peninsular Malaysia. A total of 34 isolates belonging to eight serotypes isolated from village chickens were screened for resistance towards antimicrobials including colistin according to the WHO and OIE recommendations of critical antibiotics. Weltevreden accounted for 20.6% of total isolates, followed by serovars Typhimurium and Agona (17.6%). The majority of isolates (73.5%) demonstrated resistance to one or more antimicrobials. Eight isolates (23.5%) were resistant to ≥3 antimicrobial classes. Colistin resistance (minimum inhibitory concentrations: 4-16 mg/L) was detected among five isolates (14.7%), including Weltevreden, Albany, Typhimurium, and spp. Univariable analysis of risk factors likely to influence the occurrence of MDR revealed that the flock size, poultry production system, and use of antibiotics in the farm were not significantly ( > 0.05) associated with MDR . The current study highlights that MDR occur at a lower level in village chickens compared to that found in live commercial chickens. However, MDR remains a problem even among free-range chickens with minimal exposure to antibiotics.
从食用动物中分离出的肠杆菌科细菌出现了包括对黏菌素耐药在内的多重耐药性（MDR），这对公众健康构成了严重威胁，因为这些耐药变体有可能通过食物链传播给人类。乡村鸡或马来本土鸡是放养的禽类，越来越多的消费者青睐它们，认为这些鸡肉是有机的且更有益健康。本研究调查了从马来西亚半岛中南部乡村鸡群中分离出的菌株的抗菌谱。根据世界卫生组织（WHO）和世界动物卫生组织（OIE）对关键抗生素的建议，对从乡村鸡中分离出的属于八种血清型的34株菌株进行了包括黏菌素在内的抗菌药物耐药性筛查。韦尔泰弗里登血清型占分离菌株总数的20.6%，其次是鼠伤寒血清型和阿哥纳血清型（17.6%）。大多数分离菌株（73.5%）对一种或多种抗菌药物表现出耐药性。八株分离菌株（23.5%）对≥3类抗菌药物耐药。在五株分离菌株（14.7%）中检测到黏菌素耐药（最低抑菌浓度：4 - 16 mg/L），包括韦尔泰弗里登血清型、奥尔巴尼血清型、鼠伤寒血清型和未明确的血清型。对可能影响多重耐药性发生的危险因素进行单变量分析发现，鸡群规模、家禽生产系统和农场中抗生素的使用与多重耐药性没有显著关联（P>0.05）。本研究强调，与商业活鸡相比，乡村鸡中多重耐药性的发生率较低。然而，即使在极少接触抗生素的放养家禽中，多重耐药性仍然是一个问题。
