Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.
Int J Mol Sci. 2020 Oct 15;21(20):7638. doi: 10.3390/ijms21207638.
Mitogen-activated protein kinases (MAPKs) are a group of protein kinase broadly involved in various signal pathways in eukaryotes. In plants, MAPK cascades regulate growth, development, stress responses and immunity by perceiving signals from the upstream regulators and transmitting the phosphorylation signals to the downstream signaling components. To reveal the interactions between MAPK cascades and their upstream regulators is important for understanding the functional mechanisms of MAPKs in the life span of higher plants. Typical receptor-like protein kinases (RLKs) are plasma membrane-located to perceive endogenous or exogenous signal molecules in regulating plant growth, development and immunity. MAPK cascades bridge the extracellular signals and intracellular transcription factors in many RLK-mediated signaling pathways. This review focuses on the current findings that RLKs regulate plant development through MAPK cascades and discusses questions that are worth investigating in the near future.
丝裂原活化蛋白激酶（MAPK）是一类广泛参与真核生物各种信号通路的蛋白激酶。在植物中，MAPK 级联通过感知来自上游调节剂的信号并将磷酸化信号传递到下游信号成分，来调节生长、发育、应激反应和免疫。揭示 MAPK 级联与其上游调节剂之间的相互作用，对于理解高等植物 MAPKs 的功能机制具有重要意义。典型的类受体蛋白激酶（RLKs）位于质膜上，以感知内源性或外源性信号分子，从而调节植物的生长、发育和免疫。MAPK 级联在许多 RLK 介导的信号通路中连接细胞外信号和细胞内转录因子。本综述重点介绍了 RLKs 通过 MAPK 级联调节植物发育的最新发现，并讨论了未来值得研究的问题。
