Department of Geriatrics, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Road Yi Shan 600, Shanghai, 200233, China.
BMC Geriatr. 2020 Oct 19;20(1):414. doi: 10.1186/s12877-020-01830-2.
Frailty is now seen as a significant factor in older people with diabetes, whose mortality and disability increased. This study aims to investigate the association between calf circumference (CC) with frailty in diabetic adults aged over 80 years.
A cross-sectional analysis was performed on the data of 426 diabetic adults aged over 80 years. On admission, demographic data and laboratory parameters were recorded. CC was measured on the lower right leg at the point of the maximal circumference. All participants accepted frailty assessments. Frailty was mainly defined using the Fried frailty phenotype criteria.
The CC levels were significantly lower in the frail than the non-frail (26.7 ± 4.0 vs. 31.2 ± 4.0, P < 0.001). CC was negatively correlated with the Fried frailty phenotype index (P < 0.001). Logistic regression analysis of frailty revealed that age (Odds Ratio (OR), 1.368; 95% Confidential Interval (CI) 1.002-1.869; P = 0.049), CC (OR, 0.756; 95%CI 0.598-0.956; P = 0.019) were independent impact factors of frailty after adjusting all the potential confounders. Participants with low CC tertile had a significantly higher Fried frailty phenotype index than those with high CC tertiles. The best CC cut-off value for predicting frailty was 29.3 cm, its sensitivity was 75.0%, and the specificity was 78.6%, and areas under the curve (AUC) was 0.786 (P < 0.001).
CC was strongly related to frailty in diabetic adults aged over 80 years, suggesting that CC may be helpful for monitoring physical frailty in older adults in clinical and research settings.
衰弱现在被认为是老年糖尿病患者的一个重要因素，他们的死亡率和残疾率增加。本研究旨在探讨 80 岁以上糖尿病患者的小腿围（CC）与虚弱之间的关系。
对 426 名 80 岁以上的糖尿病患者进行横断面分析。入院时记录人口统计学数据和实验室参数。CC 在右下腿最大周长处测量。所有参与者均接受虚弱评估。虚弱主要采用 Fried 虚弱表型标准定义。
虚弱组的 CC 水平明显低于非虚弱组（26.7±4.0 与 31.2±4.0，P<0.001）。CC 与 Fried 虚弱表型指数呈负相关（P<0.001）。对虚弱进行 logistic 回归分析显示，年龄（优势比（OR），1.368；95%置信区间（CI），1.002-1.869；P=0.049）和 CC（OR，0.756；95%CI，0.598-0.956；P=0.019）是调整所有潜在混杂因素后虚弱的独立影响因素。低 CC 三分位组的 Fried 虚弱表型指数明显高于高 CC 三分位组。预测虚弱的最佳 CC 截断值为 29.3cm，其敏感性为 75.0%，特异性为 78.6%，曲线下面积（AUC）为 0.786（P<0.001）。
CC 与 80 岁以上糖尿病患者的虚弱密切相关，表明 CC 可能有助于在临床和研究环境中监测老年人的身体虚弱。
