Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA.
Org Biomol Chem. 2021 Jan 6;19(1):11-36. doi: 10.1039/d0ob01807d.
While primary aliphatic amines are ubiquitous in natural products, they are traditionally considered inert to substitution chemistry. This review highlights historical and recent advances in the field of aliphatic deamination chemistry which demonstrate these moieties can be harnessed as valuable C(sp3) synthons. Cross-coupling and photocatalyzed transformations proceeding through polar and radical mechanisms are compared with oxidative deamination and other transition metal catalyzed reactions.
虽然伯脂肪胺在天然产物中普遍存在，但它们在传统上被认为对取代化学是惰性的。本综述重点介绍了脂肪脱氨化学领域的历史和最新进展，这些进展表明这些部分可以被用作有价值的 C(sp3)合成子。通过比较极性和自由基机制的交叉偶联和光催化转化与氧化脱氨和其他过渡金属催化反应，说明了这一点。
