Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562, Japan.
Department of Advanced Blood Purification Therapy, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562, Japan.
Int J Clin Oncol. 2021 Jan;26(1):199-206. doi: 10.1007/s10147-020-01798-4. Epub 2020 Oct 16.
The association between baseline frailty and health-related quality of life (HRQOL) in patients with prostate cancer (PC) remains unknown.
We retrospectively evaluated the association of pretreatment frailty with HRQOL in 409 patients with PC from February 2017 to April 2020. Frailty and HRQOL were evaluated using the geriatric 8 (G8) screening tool and QLQ-C30 questionnaire, respectively. The primary objective was comparison of G8 and QOL scores between the localized diseases (M0 group) and metastatic castration-sensitive PC (mCSPC group). Secondary objectives were to study the association of G8 and QOL scores in each group and effect of frailty (G8 ≤ 14) on worse QOL.
The median age of patients was 70 years. There were 369 (surgery: 196, radiotherapy: 156, androgen deprivation therapy alone: 17) patients in the M0 and 40 patients in the mCSPC groups. There was a significant difference between the M0 and mCSPC groups in the G8 score (14.5 vs. 12.5), functioning QOL (94 vs. 87), global QOL (75 vs. 58), and 100-symptom QOL (94 vs. 85) scores. G8 scores were significantly associated with functioning, global, and 100-symptom QOL scores in both M0 and mCSPC groups. The multivariable logistic regression analyses showed that frailty (G8 ≤ 14) was significantly associated with worse global QOL, functioning QOL, and 100-symptom QOL scores.
The baseline frailty and HRQOL were significantly different between the localized and metastatic disease. The baseline frailty was significantly associated with worse HRQOL in patients with PC.
基线虚弱与前列腺癌（PC）患者的健康相关生活质量（HRQOL）之间的关联尚不清楚。
我们回顾性评估了 2017 年 2 月至 2020 年 4 月 409 例 PC 患者的预处理虚弱与 HRQOL 的关系。使用老年 8 项（G8）筛查工具和 QLQ-C30 问卷分别评估虚弱和 HRQOL。主要目的是比较局限性疾病（M0 组）和转移性去势敏感 PC（mCSPC 组）的 G8 和 QOL 评分。次要目的是研究每组中 G8 和 QOL 评分的相关性，以及虚弱（G8≤14）对 QOL 更差的影响。
患者的中位年龄为 70 岁。M0 组有 369 例患者（手术：196 例，放疗：156 例，单独雄激素剥夺治疗：17 例），mCSPC 组有 40 例患者。M0 组和 mCSPC 组的 G8 评分（14.5 对 12.5）、功能 QOL（94 对 87）、总体 QOL（75 对 58）和 100 症状 QOL（94 对 85）评分存在显著差异。G8 评分与 M0 和 mCSPC 组的功能、总体和 100 症状 QOL 评分均显著相关。多变量逻辑回归分析显示，虚弱（G8≤14）与总体 QOL、功能 QOL 和 100 症状 QOL 评分更差显著相关。
局限性疾病和转移性疾病之间的基线虚弱和 HRQOL 有显著差异。基线虚弱与 PC 患者的 HRQOL 更差显著相关。
