非人类灵长类动物光遗传学的开放资源。
An Open Resource for Non-human Primate Optogenetics.
作者信息
Tremblay Sébastien, Acker Leah, Afraz Arash, Albaugh Daniel L, Amita Hidetoshi, Andrei Ariana R, Angelucci Alessandra, Aschner Amir, Balan Puiu F, Basso Michele A, Benvenuti Giacomo, Bohlen Martin O, Caiola Michael J, Calcedo Roberto, Cavanaugh James, Chen Yuzhi, Chen Spencer, Chernov Mykyta M, Clark Andrew M, Dai Ji, Debes Samantha R, Deisseroth Karl, Desimone Robert, Dragoi Valentin, Egger Seth W, Eldridge Mark A G, El-Nahal Hala G, Fabbrini Francesco, Federer Frederick, Fetsch Christopher R, Fortuna Michal G, Friedman Robert M, Fujii Naotaka, Gail Alexander, Galvan Adriana, Ghosh Supriya, Gieselmann Marc Alwin, Gulli Roberto A, Hikosaka Okihide, Hosseini Eghbal A, Hu Xing, Hüer Janina, Inoue Ken-Ichi, Janz Roger, Jazayeri Mehrdad, Jiang Rundong, Ju Niansheng, Kar Kohitij, Klein Carsten, Kohn Adam, Komatsu Misako, Maeda Kazutaka, Martinez-Trujillo Julio C, Matsumoto Masayuki, Maunsell John H R, Mendoza-Halliday Diego, Monosov Ilya E, Muers Ross S, Nurminen Lauri, Ortiz-Rios Michael, O'Shea Daniel J, Palfi Stéphane, Petkov Christopher I, Pojoga Sorin, Rajalingham Rishi, Ramakrishnan Charu, Remington Evan D, Revsine Cambria, Roe Anna W, Sabes Philip N, Saunders Richard C, Scherberger Hansjörg, Schmid Michael C, Schultz Wolfram, Seidemann Eyal, Senova Yann-Suhan, Shadlen Michael N, Sheinberg David L, Siu Caitlin, Smith Yoland, Solomon Selina S, Sommer Marc A, Spudich John L, Stauffer William R, Takada Masahiko, Tang Shiming, Thiele Alexander, Treue Stefan, Vanduffel Wim, Vogels Rufin, Whitmire Matthew P, Wichmann Thomas, Wurtz Robert H, Xu Haoran, Yazdan-Shahmorad Azadeh, Shenoy Krishna V, DiCarlo James J, Platt Michael L
机构信息
Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA.
McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
出版信息
Neuron. 2020 Dec 23;108(6):1075-1090.e6. doi: 10.1016/j.neuron.2020.09.027. Epub 2020 Oct 19.
Optogenetics has revolutionized neuroscience in small laboratory animals, but its effect on animal models more closely related to humans, such as non-human primates (NHPs), has been mixed. To make evidence-based decisions in primate optogenetics, the scientific community would benefit from a centralized database listing all attempts, successful and unsuccessful, of using optogenetics in the primate brain. We contacted members of the community to ask for their contributions to an open science initiative. As of this writing, 45 laboratories around the world contributed more than 1,000 injection experiments, including precise details regarding their methods and outcomes. Of those entries, more than half had not been published. The resource is free for everyone to consult and contribute to on the Open Science Framework website. Here we review some of the insights from this initial release of the database and discuss methodological considerations to improve the success of optogenetic experiments in NHPs.
光遗传学已经彻底改变了小型实验动物的神经科学研究，但它对与人类关系更密切的动物模型（如非人类灵长类动物，NHPs）的影响却喜忧参半。为了在灵长类动物光遗传学研究中做出基于证据的决策，科学界将受益于一个集中式数据库，该数据库列出了在灵长类动物大脑中使用光遗传学的所有尝试，包括成功和失败的尝试。我们联系了该领域的成员，请求他们为一项开放科学倡议做出贡献。截至撰写本文时，全球45个实验室贡献了1000多个注射实验，包括有关其方法和结果的精确细节。在这些条目中，超过一半尚未发表。该资源可供所有人在开放科学框架网站上免费查阅和贡献。在这里，我们回顾了该数据库首次发布的一些见解，并讨论了提高NHPs光遗传学实验成功率的方法学考虑因素。
Zotero 插件