Department of Pharmacy, Federal University of Rio Grande do Norte, Natal, RN59012-570, Brazil.
Department of Civil, Chemical and Environmental Engineering, University of Genoa, Genova, I-16145, Italy.
Curr Pharm Des. 2021;27(19):2289-2298. doi: 10.2174/1381612826666201020163331.
Ferulic acid is a phenolic compound widely distributed in monocotyledons, with several applications, especially in pharmaceutical and dermo-cosmetic industries. It has proven antioxidant and anti- inflammatory activities, among others, which are mainly ascribed to its molecular structure. The main factor that can lead to serious skin damages like inflammation, dryness, wrinkles, and cancer is the exposure to UV radiation that is responsible for an increased level of radical oxygen species.
This review aims to evaluate the application of ferulic acid in topical formulations and the technologies used to enhance its bioavailability and stability, as well as to get a clearer picture of its effects by in vivo and in vitro studies.
It covers technological publications in the WIPO, EPO, INPI, and USPTO databases and scientific publications in the PubMed, Web of Sciences, and Science Direct databases, exploring the trend and application of this compound by country and year of publication.
Both the scientific and technological analyses showed the importance and tendency in the association of the Ferulic Acid and other vitamins and actives. The synergic effect certainly provides a better result, performance, and stability of the compounds, which cleared the great spectrum and applicability of the Ferulic Acid in topical formulations.
The present literature survey revealed that ferulic acid exerts an important activity in several formulations for topical application and improved the stability and bioavailability when combined with new technologies and methods, showing an open path to target the treatment of skin disorders.
阿魏酸是一种广泛分布于单子叶植物中的酚类化合物，具有多种应用，尤其在制药和皮肤护理行业。它已被证明具有抗氧化和抗炎等活性，主要归因于其分子结构。导致皮肤严重损伤的主要因素是暴露于紫外线辐射，这会导致自由基氧物种水平升高。
本综述旨在评估阿魏酸在局部制剂中的应用，以及用于提高其生物利用度和稳定性的技术，同时通过体内和体外研究更清楚地了解其作用。
它涵盖了 WIPO、EPO、INPI 和 USPTO 数据库中的技术出版物，以及 PubMed、Web of Sciences 和 Science Direct 数据库中的科学出版物，通过国家和出版年份探索了该化合物的趋势和应用。
科学和技术分析都表明了阿魏酸与其他维生素和活性剂联合的重要性和趋势。协同作用无疑为化合物提供了更好的效果、性能和稳定性，这清楚地表明了阿魏酸在局部制剂中的广泛光谱和适用性。
本文献综述表明，阿魏酸在几种局部应用制剂中具有重要的活性，并在与新技术和方法结合使用时提高了稳定性和生物利用度，为靶向皮肤疾病治疗开辟了一条新途径。
