Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Mini Rev Med Chem. 2021;21(12):1578-1593. doi: 10.2174/1389557521666210120111702.
The compound 4-hydroxy-3-methoxycinnamic acid, named ferulic acid (FA), is a ubiquitous phenolic compound distributed extensively in the plant kingdom. Ferulic acid is a boon. It has immense potential therapeutic effects in treating diabetes, cancer, pulmonary and CVS diseases majorly due to its antioxidant and anti-inflammatory action. Ferulic acid exhibits a wide variety of biological activities such as, anticarcinogenic, antiallergic, antimicrobial, antiviral, hepatoprotective, metal chelation, activation of transcriptional factors, modulation of enzyme activity, gene expression as well as signal transduction. This active ingredient's structural characteristics make it an optimal substrate to form or synthesise various derivatives and its formulations. The present review addresses structure of ferulic acid, its pharmacodynamic parameters, applications, and its various derivatives. Besides, the review also aims to cover the main aspects related to the use of ferulic acid in the food and health industry and lists various published patents on Ferulic acid.
4-羟基-3-甲氧基肉桂酸，名为阿魏酸（FA），是一种广泛存在的酚类化合物，分布于植物界中。阿魏酸是一种恩赐。由于其抗氧化和抗炎作用，它在治疗糖尿病、癌症、肺部和心血管疾病方面具有巨大的潜在治疗效果。阿魏酸表现出多种生物活性，如抗癌、抗过敏、抗菌、抗病毒、保肝、金属螯合、转录因子激活、酶活性调节、基因表达以及信号转导。这种活性成分的结构特征使其成为形成或合成各种衍生物及其制剂的理想基质。本综述介绍了阿魏酸的结构、药效参数、应用及其各种衍生物。此外，该综述还旨在涵盖阿魏酸在食品和健康产业中的应用的主要方面，并列出了关于阿魏酸的各种已公布专利。
