母体特异性细胞介导免疫向胎儿的转移。
Transfer of maternal specific cell-mediated immunity to the fetus.
作者信息
Pabst H F, Godel J C, Spady D W, Cho K
机构信息
Department of Pediatrics, University of Alberta, Canada.
出版信息
Clin Exp Immunol. 1987 Apr;68(1):209-14.
The extent of specific cell-mediated immunity was measured in 67 consecutive newborns and their mothers. The stimulation index of blast transformation of the infants' lymphocytes in the presence of purified protein derivative, Candida extract and streptokinase was greater than 2.0 in 54%, 18% and 23% respectively. This was seen only in infants whose mothers' index was also greater than 2.0 to the same antigen. Leucocyte inhibition factor generated from lymphocytes of four babies in the presence of purified protein derivative inhibited migration of indicator cells over 50%; their stimulation index with purified protein derivative was greater than 2.0. Newborns have cell mediated immunity to the same antigens as their mothers, and this wanes during the first few months of life.
对67名连续的新生儿及其母亲进行了特异性细胞介导免疫程度的检测。在存在纯化蛋白衍生物、念珠菌提取物和链激酶的情况下，婴儿淋巴细胞的 blast 转化刺激指数分别在54%、18%和23%的情况下大于2.0。这仅在其母亲对相同抗原的指数也大于2.0的婴儿中观察到。在存在纯化蛋白衍生物的情况下，来自四名婴儿淋巴细胞产生的白细胞抑制因子抑制指示细胞迁移超过50%；他们对纯化蛋白衍生物的刺激指数大于2.0。新生儿对与其母亲相同的抗原有细胞介导免疫，且这种免疫在生命的最初几个月中逐渐减弱。
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