Grindulis H, Baynham M I, Scott P H, Thompson R A, Wharton B A
Arch Dis Child. 1984 Jul;59(7):614-9. doi: 10.1136/adc.59.7.614.
One hundred and forty nine Asian children who received BCG vaccine shortly after birth were reviewed at the age of 22 months. Many of them had an apparently inadequate response to the vaccine. A quarter had no scar, and half of the children with a scar had a negative response to 10 TU (Mantoux 1/1000) and these children showed only limited lymphocyte transformation in vitro in response to tuberculin. Various measurements of health at age 22 months suggested the Mantoux negative children were less privileged than the Mantoux positive ones, but the differences were not striking and most were not significant. It seemed more likely that the high incidence of poor response was due to some factor operating in the perinatal period. There was circumstantial evidence implicating perinatal nutrition, and there is a theoretical possibility of interference with vaccination by maternal antibody.
对149名出生后不久接种卡介苗的亚洲儿童在22个月龄时进行了复查。他们中的许多人对疫苗的反应明显不足。四分之一的儿童没有疤痕，有疤痕的儿童中有一半对10 TU（曼托试验1/千）呈阴性反应，并且这些儿童在体外对结核菌素的淋巴细胞转化反应有限。22个月龄时的各项健康指标表明，曼托试验阴性的儿童比阳性儿童的情况要差，但差异并不显著，大多数差异无统计学意义。反应不佳的高发生率似乎更可能是由于围产期存在某种影响因素。有间接证据表明围产期营养与之有关，并且存在母体抗体干扰疫苗接种的理论可能性。
