犬血红蛋白A1c的参考区间及其血液学参数对其血清浓度的影响。

Small Animal Clinic, Institute of Veterinary Medicine, University of Goettingen, Burckhardtweg 2, D-37077, Goettingen, Germany.

Vet Med Int. 2020 Oct 7;2020:7150901. doi: 10.1155/2020/7150901. eCollection 2020.

HbA1c could be an alternative to fructosamine as a marker for glucose levels over a longer period. In this study, we calculated a reference interval for HbA1c in dogs and investigated the correlation of HbA1c with hemoglobin and different hematological parameters. In total, 110 blood samples from dogs were investigated. Significant negative correlations were found between HbA1c and erythrocyte count, hemoglobin concentration, as well as hematocrit. There was a tendency in the red cell distribution width. No significant correlation was found in the reticulocyte number and the erythrocyte indices. In conclusion, there is an association of different blood parameters with the HbA1c concentration, which have to be considered for the interpretation of HbA1c.

糖化血红蛋白（HbA1c）可作为果糖胺的替代指标，用于长期监测血糖水平。在本研究中，我们计算了犬类HbA1c的参考区间，并研究了HbA1c与血红蛋白及不同血液学参数之间的相关性。总共对110份犬类血液样本进行了研究。结果发现，HbA1c与红细胞计数、血红蛋白浓度以及血细胞比容之间存在显著负相关。红细胞分布宽度存在一定趋势。网织红细胞数量和红细胞指数未发现显著相关性。总之，不同血液参数与HbA1c浓度之间存在关联，在解释HbA1c结果时必须予以考虑。