Research Center of Nano Science and Technology, College of Sciences, Shanghai University, Shanghai 200444, China.
J Mater Chem B. 2020 Dec 7;8(45):10257-10270. doi: 10.1039/d0tb01745k. Epub 2020 Oct 21.
The near-infrared II (NIR-II) light (1000-1700 nm) possesses deep penetration capability and high signal-to-noise ratios due to the advances of low autofluorescence and scattering in biological tissues. Differing from the traditional NIR-II-emitting nanoprobes such as carbon nanotubes (CNT), organic dyes, quantum dots (QDs), and polymer dots (PDs), lanthanide-doped NPs feature the characteristic of excellent photo-and-chemical stability, sharp emission peaks, longer lifetime, and larger anti-Stokes shift. These merits have impelled the development of NIR-II-emitting lanthanide NPs in biomedical applications at a terrific speed. In this mini-review, we discuss how to design efficient NIR-II-emitting lanthanide NPs and summarize their recent progress in bioimaging, therapy, and biosensing. Moreover, the limitations and future opportunities of NIR-II-emitting lanthanide NPs are also discussed.
近红外二区 (NIR-II) 光 (1000-1700nm) 由于生物组织中自发荧光和散射的降低，具有较深的穿透能力和较高的信噪比。与传统的近红外二区发光纳米探针（如碳纳米管 (CNT)、有机染料、量子点 (QDs) 和聚合物点 (PDs)）不同，镧系掺杂 NPs 具有优异的光化学稳定性、尖锐的发射峰、较长的寿命和较大的反斯托克斯位移等特点。这些优点促使近红外二区发光镧系 NPs 在生物医学应用中的发展速度非常快。在这篇小综述中，我们讨论了如何设计高效的近红外二区发光镧系 NPs，并总结了它们在生物成像、治疗和生物传感方面的最新进展。此外，还讨论了近红外二区发光镧系 NPs 的局限性和未来的机遇。
