Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore, Singapore.
Arch Virol. 2021 Jan;166(1):225-229. doi: 10.1007/s00705-020-04855-5. Epub 2020 Oct 21.
Genome sequences of members of a potential fourth rhinovirus (RV) species, provisionally denoted as rhinovirus A clade D, from patients with acute respiratory infection were determined. Bayesian coalescent analysis estimated that clade D emerged around the 1940s and diverged further around 2006-2007 into two distinctive sublineages (RV-A8-like and RV-A45-like) that harbored unique "clade-defining" substitutions. Similarity plots and bootscan mapping revealed a recombination breakpoint located in the 5'-UTR region of members of the RV-A8-like sublineage. Phylogenetic reconstruction revealed the distribution of clade D viruses in the Asia Pacific region and in Europe, underlining its worldwide distribution.
从急性呼吸道感染患者中分离出了一种潜在的第四种鼻病毒（RV）成员的基因组序列，暂命名为鼻病毒 A 谱系 D。贝叶斯系统发育分析估计，谱系 D 大约在 20 世纪 40 年代出现，随后在 2006-2007 年进一步分化为两个独特的亚谱系（RV-A8 样和 RV-A45 样），它们具有独特的“谱系定义”取代。相似性图谱和引导扫描映射显示，在 RV-A8 样亚谱系成员的 5'-UTR 区域存在一个重组断点。系统发育重建显示，谱系 D 病毒在亚太地区和欧洲的分布，强调了其在全球的分布。
