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在糖尿病犬中进行瞬感葡萄糖监测:评估血糖控制的一种可行方法。

Flash glucose monitoring in diabetic dogs: a feasible method for evaluating glycemic control.

机构信息

Diabetes mellitus, sensorbasiertes Glukosemonitoring, glykämische Variabilität, MAGE.

出版信息

Tierarztl Prax Ausg K Kleintiere Heimtiere. 2020 Oct;48(5):330-338. doi: 10.1055/a-1239-4739. Epub 2020 Oct 21.

Abstract

OBJECTIVE

To alleviate clinical signs and avoid life-threatening complications in dogs with diabetes mellitus, individualized treatment plans and frequent reassessments are necessary. Performing blood glucose profiles every 7-14 days following insulin adjustments and monthly thereafter, is recommended. In 2016, a factory calibrated continuous blood glucose monitoring system was presented as a possible alternative to glucometer readings. The objectives of this study were to summarize the experiences with this new technology and to show, that in combination with simple rules, already the first measurement period can improve glycemic control.

MATERIAL AND METHODS

The electronic database of the endocrine unit of the clinic was retrospectively searched for diabetic dogs with flash glucose monitoring. In case of repeated sensor implantations, only the first sensor was considered. The recordings of day A (starting at midnight after sensor placement) were compared to the measurements of day B (day before sensor failure) and all owners were contacted to fill in a standardized questionnaire.

RESULTS

The final study population consisted of 24 dogs weighing 3.4 to 36 kg. Although the clicking noise during sensor placement irritated most dogs, the application was considered easy and painless. Waiting for disinfectant evaporation and fixation of the sensor disc with forceps helped to avoid sensor detachment when removing the application device. Although transient mild to moderate skin irritations were observed in 80 % of the dogs, 95 % of the owners were highly satisfied with this new monitoring technology. Mean and maximum glucose (p = 0.043, p = 0.003) as well as glucose readings ≥ 11.1 mmol/l (p = 0.032) decreased from day A to B, whereas markers of glycemic variability did not change.

CONCLUSION AND CLINICAL RELEVANCE

Flash glucose monitoring is a feasible, safe method with high user satisfaction and offers a possibility to improve glycemic control in diabetic dogs.

摘要

目的

为了缓解糖尿病犬的临床症状并避免危及生命的并发症,有必要制定个体化的治疗方案并进行频繁的重新评估。建议在调整胰岛素后每 7-14 天进行一次血糖谱检查,此后每月一次。2016 年,一种工厂校准的连续血糖监测系统被提出作为血糖仪读数的替代方案。本研究的目的是总结这项新技术的经验,并展示在结合简单规则的情况下,第一次测量就可以改善血糖控制。

材料和方法

回顾性地在诊所的内分泌科电子数据库中搜索使用 flash 血糖监测的糖尿病犬。在重复植入传感器的情况下,仅考虑第一次植入的传感器。比较第 A 天(传感器放置后午夜开始)的记录与第 B 天(传感器失效前一天)的测量值,并联系所有主人填写标准化问卷。

结果

最终的研究人群由 24 只体重 3.4 至 36 公斤的犬组成。尽管传感器放置时的咔嗒声会刺激大多数犬,但应用过程被认为是简单无痛的。等待消毒剂蒸发并用镊子固定传感器盘有助于在移除应用设备时避免传感器脱落。尽管 80%的犬出现短暂的轻度至中度皮肤刺激,但 95%的主人对这项新的监测技术非常满意。平均和最大血糖(p=0.043,p=0.003)以及血糖读数≥11.1mmol/l(p=0.032)从第 A 天到第 B 天下降,而血糖变异性的标志物没有变化。

结论和临床意义

Flash 血糖监测是一种可行、安全的方法,具有高用户满意度,并为改善糖尿病犬的血糖控制提供了可能性。

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