Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan.
Department of Internal Medicine, Miyazaki Prefectural Nobeoka Hospital, Nobeoka 882-0835, Japan.
Nutrients. 2020 Oct 19;12(10):3187. doi: 10.3390/nu12103187.
The relationships between serum zinc levels and body composition or clinical outcomes of incident hemodialysis (HD) patients remain unclear.
This prospective observational study examined the relationships between serum zinc levels and clinical indexes, including body composition, in 142 incident HD patients using a bioelectrical impedance analysis. Patients were divided into three groups according to baseline serum zinc levels: tertile, <45, 45-59, and ≥60 µg/dL. The reference group was set as ≥60 µg/dL. Cox's regression analysis was performed to investigate the relationships between serum zinc categories and cardiovascular events and all-cause mortality after adjustments for potential confounders.
Serum zinc levels positively correlated with the nutritional index and negatively correlated with fluid volume markers. In a mean follow-up of 2.5 years, there were 20 cases of cardiovascular events and 15 of all-cause mortality. In the Cox's regression analysis for cardiovascular events and all-cause mortality, the hazard ratio increased with a decrease in serum zinc levels, but was not significant.
Serum zinc levels were associated with nutritional and fluid volume markers in incident HD patients. To clarify the relationship between serum zinc levels and cardiovascular events or mortality, further studies with a larger number of cases will be necessary.
血清锌水平与新进入血液透析（HD）患者的身体成分或临床结局之间的关系尚不清楚。
本前瞻性观察研究使用生物电阻抗分析检查了 142 例新进入 HD 患者的血清锌水平与包括身体成分在内的临床指标之间的关系。根据基线血清锌水平将患者分为三组：三分位组，<45、45-59 和≥60μg/dL。参考组设为≥60μg/dL。进行 Cox 回归分析以研究血清锌类别与心血管事件和全因死亡率之间的关系，在调整了潜在混杂因素后。
血清锌水平与营养指数呈正相关，与液体量标志物呈负相关。在平均 2.5 年的随访中，发生了 20 例心血管事件和 15 例全因死亡。在心血管事件和全因死亡率的 Cox 回归分析中，随着血清锌水平的降低，风险比增加，但无统计学意义。
血清锌水平与新进入 HD 患者的营养和液体量标志物有关。为了阐明血清锌水平与心血管事件或死亡率之间的关系，需要进行更多病例的进一步研究。
