Khayamzadeh Mina, Mirzaii-Dizgah Iraj, Aghababainejad Pegah, Habibzadeh Sareh, Kharazifard Mohammad Javad
Department of Oral Medicine, School of Dentistry, International Campus, Tehran University of Medical Sciences, Tehran, Iran.
Department of Physiology, AJA University of Medical Sciences, Tehran, Iran.
Front Dent. 2019 Nov-Dec;16(6):465-472. doi: 10.18502/fid.v16i6.3446. Epub 2019 Dec 20.
Parafunctional habits, as one of the etiological factors of temporomandibular disorders (TMD), are an individual's response to increased stress. During stress and depression, biomarkers such as cortisol and salivary alpha-amylase (SAA) are secreted in the saliva. The present study aimed to investigate whether there is a correlation between salivary stress biomarkers and parafunctional habits.
Thirty-two cases, from May to September 2015, were selected based on two standard stress questionnaires, namely the depression anxiety stress Scale-21 (DASS-21) and the Beck Anxiety Inventory (BAI). Saliva samples were collected to examine the level of unstimulated salivary cortisol and SAA. The significance of the results was assessed via student's t-test and Mann-Whitney test (α=0.05).
The mean concentrations of cortisol and SAA in unstimulated saliva were significantly higher in the case group than in the control group (P=0.01 and 0.44, respectively). The mean scores of anxiety, stress, and depression were significantly higher in the case group than in the control group (P<0.05).
It seems that the levels of salivary cortisol and SAA, as well as stress, anxiety, and depression scores, are higher in patients with parafunctional habits.
副功能习惯作为颞下颌关节紊乱病（TMD）的病因之一，是个体对压力增加的一种反应。在应激和抑郁状态下，唾液中会分泌皮质醇和唾液α淀粉酶（SAA）等生物标志物。本研究旨在探讨唾液应激生物标志物与副功能习惯之间是否存在相关性。
2015年5月至9月，根据两份标准应激问卷，即抑郁焦虑压力量表-21（DASS-21）和贝克焦虑量表（BAI），选取了32例患者。收集唾液样本以检测非刺激性唾液皮质醇和SAA水平。通过学生t检验和曼-惠特尼检验评估结果的显著性（α=0.05）。
病例组非刺激性唾液中皮质醇和SAA的平均浓度显著高于对照组（分别为P=0.01和0.44）。病例组焦虑、压力和抑郁的平均得分显著高于对照组（P<0.05）。
似乎有副功能习惯的患者唾液皮质醇和SAA水平以及压力、焦虑和抑郁得分更高。
