School of Public Health, Guangxi Medical University, 22 Shuangyong Rd, Qingxiu District, Nanning 530021, China.
Department of Quantitative Health Sciences, University of Hawaii John A. Burns School of Medicine, 651 Ilalo Street, Honolulu, HI 96813, USA.
Molecules. 2020 Oct 21;25(20):4864. doi: 10.3390/molecules25204864.
Lipids are essential components of cell structure and play important roles in signal transduction between cells and body metabolism. With the continuous development and innovation of lipidomics technology, many studies have shown that the relationship between lipids and cancer is steadily increasing, involving cancer occurrence, proliferation, migration, and apoptosis. Breast cancer has seriously affected the safety and quality of life of human beings worldwide and has become a significant public health problem in modern society, with an especially high incidence among women. Therefore, the issue has inspired scientific researchers to study the link between lipids and breast cancer. This article reviews the research progress of lipidomics, the biological characteristics of lipid molecules, and the relationship between some lipids and cancer drug resistance. Furthermore, this work summarizes the lipid molecules related to breast cancer diagnosis and prognosis, and then it clarifies their impact on the occurrence and development of breast cancer The discussion revolves around the current research hotspot long-chain non-coding RNAs (lncRNAs), summarizes and explains their impact on tumor lipid metabolism, and provides more scientific basis for future cancer research studies.
脂质是细胞结构的重要组成部分,在细胞间信号转导和机体代谢中发挥着重要作用。随着脂质组学技术的不断发展和创新,许多研究表明脂质与癌症之间的关系日益密切,涉及癌症的发生、增殖、迁移和凋亡。乳腺癌已严重影响到全球人类的安全和生活质量,成为现代社会的重大公共卫生问题,尤其在女性中发病率较高。因此,这一问题激发了科学研究人员研究脂质与乳腺癌之间的联系。本文综述了脂质组学的研究进展、脂质分子的生物学特性以及部分脂质与癌症耐药性的关系。此外,本文还总结了与乳腺癌诊断和预后相关的脂质分子,然后阐明它们对乳腺癌发生和发展的影响。讨论围绕当前的研究热点——长链非编码 RNA(lncRNA)展开,总结并解释其对肿瘤脂质代谢的影响,为未来癌症研究提供更多科学依据。