Neuroscience Center, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Department of Informatics, Bioengineering, Robotics and System engineering, University of Genoa, Genoa, Italy.
Nat Commun. 2020 Oct 23;11(1):5363. doi: 10.1038/s41467-020-18975-8.
Inter-areal synchronization of neuronal oscillations at frequencies below ~100 Hz is a pervasive feature of neuronal activity and is thought to regulate communication in neuronal circuits. In contrast, faster activities and oscillations have been considered to be largely local-circuit-level phenomena without large-scale synchronization between brain regions. We show, using human intracerebral recordings, that 100-400 Hz high-frequency oscillations (HFOs) may be synchronized between widely distributed brain regions. HFO synchronization expresses individual frequency peaks and exhibits reliable connectivity patterns that show stable community structuring. HFO synchronization is also characterized by a laminar profile opposite to that of lower frequencies. Importantly, HFO synchronization is both transiently enhanced and suppressed in separate frequency bands during a response-inhibition task. These findings show that HFO synchronization constitutes a functionally significant form of neuronal spike-timing relationships in brain activity and thus a mesoscopic indication of neuronal communication per se.
神经元振荡在~100 Hz 以下的区域间同步是神经元活动的普遍特征，被认为可以调节神经元回路中的通讯。相比之下，更快的活动和振荡被认为主要是局部回路级别的现象，而大脑区域之间没有大规模的同步。我们使用人类颅内记录显示，100-400 Hz 的高频振荡（HFOs）可能在广泛分布的大脑区域之间同步。HFO 同步表达个体频率峰值，并表现出可靠的连接模式，显示出稳定的社区结构。HFO 同步还具有与较低频率相反的分层特征。重要的是，在反应抑制任务中，HFO 同步在不同的频带中会暂时增强和抑制。这些发现表明，HFO 同步构成了大脑活动中神经元尖峰时间关系的一种功能显著形式，因此是神经元通讯本身的一种介观指标。
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