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. 对平滑肌和血小板聚集的药理学调节

Pharmacological Modulation of Smooth Muscles and Platelet Aggregation by .

作者信息

Rahman Hafiz Muhammad Abdur, Saghir Khaled Ahmed, Haider Muhammad Sajjad, Javaid Usman, Rasool Muhammad Fawad, Alqahtani Faleh, Imran Imran

机构信息

Department of Pharmacology, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan.

Department of Pharmacy, Southern Punjab Institute of Health Sciences, Multan, Pakistan.

出版信息

Evid Based Complement Alternat Med. 2020 Oct 8;2020:4291795. doi: 10.1155/2020/4291795. eCollection 2020.

DOI:10.1155/2020/4291795
PMID:33101443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7568158/
Abstract

Traditionally, in the Southern Asian countries, is a widely used plant for the management of various ailments such as gastrointestinal, respiratory, and cardiac disorders, but it lacks proof on a scientific basis, and therefore, this is the major emphasis of the current research work. Crude extract of (Pc.Cr) was preliminary analyzed for the presence of different classes of bioactive molecules. The aqueous and dichloromethane fractions of Pc.Cr were subjected to and studies. It was applied at variable concentrations (0.1-10 mg/ml) to isolated rabbit jejunum to investigate spasmolytic effect. Concentration dependent curves of calcium were constructed to check the calcium channel antagonistic activity. For the evaluation of tracheorelaxant activity, isolated tracheal tissue was treated with High-K (80 mM) and carbachol (CCh) and then challenged cumulatively with Pc.Cr. To study the antidiarrheal effect of the plant extract, castor oil-induced diarrhea model was adopted. For evaluation of the hypotensive effect of Pc.Cr, it was given intravenously to preanesthetized normotensive rats, and the response was recorded using pressure transducer. Platelet rich plasma was used for the assessment of the antiplatelet activity when challenged with purinergic and adrenergic agonists. Concentration-dependent inhibition of spontaneous and High-K mediated contractions in isolated jejunum was observed by the application of Pc.Cr. Contractions induced in isolated tracheal tissue by High-K and CCh were inhibited by application of Pc.Cr to these tissues. Similarly, application of Pc.Cr to High-K and phenylephrine (PE) treated aortic strips resulted in vasodilation. Platelet aggregation inhibition was shown by Pc.Cr against adenosine diphosphate (ADP) only. The antidiarrheal effect was observed as a reduction in the total number of feces in Pc.Cr-treated mice when given castor oil. Dose-dependent hypotension was seen in normotensive rats when treated with Pc.Cr intravenously. This study showed the spasmolytic, tracheorelaxant, vasodilator, platelet aggregation inhibitory, antidiarrheal, and hypotensive activities of which may be due to the blockage of calcium channels, but the involvement of any other pathway cannot be ignored.

摘要

传统上，在南亚国家，[植物名称未给出]是一种广泛用于治疗各种疾病的植物，如胃肠道、呼吸道和心脏疾病，但缺乏科学依据，因此，这是当前研究工作的主要重点。对[植物名称未给出]的粗提物（Pc.Cr）进行了不同类生物活性分子的初步分析。Pc.Cr的水相和二氯甲烷馏分进行了[具体研究未给出]和[具体研究未给出]研究。将其以不同浓度（0.1 - 10毫克/毫升）应用于离体兔空肠，以研究解痉作用。构建钙浓度依赖性曲线以检查钙通道拮抗活性。为评估气管舒张活性，将离体气管组织用高钾（80毫摩尔）和卡巴胆碱（CCh）处理，然后用Pc.Cr进行累积刺激。为研究该植物提取物的止泻作用，采用蓖麻油诱导的腹泻模型。为评估Pc.Cr的降压作用，将其静脉注射给预先麻醉的正常血压大鼠，并使用压力传感器记录反应。当用嘌呤能和肾上腺素能激动剂刺激时，富含血小板的血浆用于评估抗血小板活性。应用Pc.Cr可观察到离体空肠中自发和高钾介导的收缩呈浓度依赖性抑制。将Pc.Cr应用于这些组织可抑制高钾和CCh在离体气管组织中诱导的收缩。同样，将Pc.Cr应用于高钾和去氧肾上腺素（PE）处理的主动脉条带导致血管舒张。Pc.Cr仅对腺苷二磷酸（ADP）显示出抑制血小板聚集作用。当给蓖麻油时，在Pc.Cr处理的小鼠中观察到止泻作用表现为粪便总数减少。当用Pc.Cr静脉注射处理正常血压大鼠时，出现剂量依赖性低血压。本研究表明[植物名称未给出]具有解痉、气管舒张、血管舒张、抑制血小板聚集、止泻和降压活性，这可能是由于钙通道的阻断，但任何其他途径的参与也不能被忽视。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c8/7568158/0ae1f1581ce6/ECAM2020-4291795.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c8/7568158/ed0440ae7a22/ECAM2020-4291795.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c8/7568158/78f46776ba78/ECAM2020-4291795.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c8/7568158/60878a7853ef/ECAM2020-4291795.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c8/7568158/0ae1f1581ce6/ECAM2020-4291795.010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c8/7568158/43a67d809989/ECAM2020-4291795.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c8/7568158/7c9e3dac2759/ECAM2020-4291795.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c8/7568158/c9b2c5913e1f/ECAM2020-4291795.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c8/7568158/f81764355944/ECAM2020-4291795.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c8/7568158/fb1291d3456b/ECAM2020-4291795.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c8/7568158/78f46776ba78/ECAM2020-4291795.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c8/7568158/60878a7853ef/ECAM2020-4291795.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c8/7568158/0ae1f1581ce6/ECAM2020-4291795.010.jpg

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