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MLC901在增加创伤性脑损伤大鼠神经发生中的作用。

Role of MLC901 in increasing neurogenesis in rats with traumatic brain injury.

作者信息

Rosyidi Rohadi Muhammad, Priyanto Bambang, Islam Andi Asadul, Hatta Mochammad, Bukhari Agussalim, Prihastomo Krisna Tsaniadi, Nasution Rizha Anshori, Prihatina Lale Maulin

机构信息

Medical Faculty of Hasanuddin University, Makassar, Indonesia.

Department of Neurosurgery Medical Faculty of Mataram University, West Nusa Tenggara Providence General Hospital, Mataram, Indonesia.

出版信息

Ann Med Surg (Lond). 2020 Oct 19;60:36-40. doi: 10.1016/j.amsu.2020.10.013. eCollection 2020 Dec.

DOI:10.1016/j.amsu.2020.10.013
PMID:33101671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7578557/
Abstract

BACKGROUND

Traumatic brain injury is a dangerous life threatening condition. This study examines the role of MLC901 in increasing neurogenesis. The aim of this study was to demonstrate the role of MLC901 in increasing neuron cell (neurogenesis) in rat with traumatic brain injury using the synaptophysin marker.

METHODS

The synaptophysin levels were measured as a marker for neuron cell (neurogenesis) of brain nerve cells in Sprague-Dawley rats aged 10-12 weeks, weighing 200-300 g. All rats (n = 10) were performed as traumatic brain injury using The Modified Marmourou Model, then they were divided into 2 group, one group was given MLC901 (n = 5) and the other group was not given MLC901 (n = 5). The synaptophysin levels in both groups were assessed after 6 weeks and also carried out an examination of immnuhistochemical from the brain tissue of both groups.

RESULTS

There was an increase in the number of neuron cells as evidenced by synaptophysin ihc staining in the rats given MLC 901 (Neuroaid II) compared to those without MLC 901. Synaptophysin levels were lower in the control group than in the MLC 901 group (81.6, SD: 13.52 vs 118.4, SD: 12.198, p = 0.062).

CONCLUSION

These research suggest that MLC901 can increase neurogenesis in traumatic brain injury and also appeared as synaptophysin antibody that binding to cytoplasm of neuronal cells in the rat brain.

摘要

背景

创伤性脑损伤是一种危及生命的危险状况。本研究探讨了MLC901在促进神经发生中的作用。本研究的目的是使用突触素标记物，证明MLC901在创伤性脑损伤大鼠中增加神经元细胞（神经发生）的作用。

方法

以10-12周龄、体重200-300克的Sprague-Dawley大鼠的脑神经细胞的神经元细胞（神经发生）标记物来测量突触素水平。所有大鼠（n = 10）采用改良的Marmourou模型进行创伤性脑损伤，然后分为2组，一组给予MLC901（n = 5），另一组不给予MLC901（n = 5）。6周后评估两组的突触素水平，并对两组脑组织进行免疫组织化学检查。

结果

与未给予MLC 901的大鼠相比，给予MLC 901（Neuroaid II）的大鼠中，突触素免疫组化染色显示神经元细胞数量增加。对照组的突触素水平低于MLC 901组（81.6，标准差：13.52 vs 118.4，标准差：12.198，p = 0.062）。

结论

这些研究表明，MLC901可以增加创伤性脑损伤中的神经发生，并且还表现为与大鼠脑中神经元细胞质结合的突触素抗体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef92/7578557/dd805c971c4d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef92/7578557/53281b9fe7b1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef92/7578557/de17b0b2266e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef92/7578557/dd805c971c4d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef92/7578557/53281b9fe7b1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef92/7578557/de17b0b2266e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef92/7578557/dd805c971c4d/gr3.jpg

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