Hussain Habiba, Sehring Matthew, Aulakh Bhagat Singh
Department of Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, USA.
Department of Pulmonary & Critical Care Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, USA.
Case Rep Crit Care. 2020 Oct 17;2020:8876932. doi: 10.1155/2020/8876932. eCollection 2020.
The Coronavirus disease (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has led to tremendous morbidity and mortality. Various inflammatory markers have been monitored and considered to be associated with disease prognosis. One of the major sources of comorbidity involved has been development of thrombosis alongside the infection. This prothrombotic phenomenon considered, COVID-19-associated coagulopathy (CAC), has been the center of discussion in dealing with this infection. There still remains ambiguity regarding management guidelines for thromboprophylaxis dosing and therapeutic anticoagulation. We present a case of severe SARS-CoV-2 infection complicated by thrombosis despite therapeutic anticoagulation contributing to prolonged intensive care unit and hospital stay.
由严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的冠状病毒病(COVID-19)大流行已导致巨大的发病率和死亡率。各种炎症标志物已被监测并被认为与疾病预后相关。所涉及的合并症的主要来源之一是感染同时发生血栓形成。考虑到这种促血栓形成现象,COVID-19相关凝血病(CAC)一直是应对这种感染的讨论焦点。关于血栓预防剂量和治疗性抗凝的管理指南仍存在模糊性。我们报告一例严重SARS-CoV-2感染病例,尽管进行了治疗性抗凝,但仍并发血栓形成,导致重症监护病房和住院时间延长。