Ministry of Education Key Laboratory of Molecular Animal Nutrition, College of Animal Science, Zhejiang University, Hangzhou, China.
Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
Front Cell Infect Microbiol. 2020 Sep 25;10:538077. doi: 10.3389/fcimb.2020.538077. eCollection 2020.
The intestine is a particularly dynamic environment in which the host constantly interacts with trillions of symbiotic bacteria called the microbiota. Using quorum sensing (QS) communication, bacteria can coordinate their social behavior and influence host cell activities in a non-invasive manner. Nowadays, a large amount of research has greatly spurred the understanding of how bacterial QS communication regulates bacterial cooperative behaviors due to coexistence and host-microbe interactions. In this review, we discuss bacterial QS in the gut and its role in biofilm formation. As a biological barrier, the mucosal immune system can effectively prevent pathogenic microorganisms and other immunogenic components from entering the internal environment of the host. We focus on the relationship between biofilm and intestinal mucosal immunity, and how probiotic bacteria may regulate them. This review is to provide a theoretical basis for the development of new techniques including probiotics targeting the intestinal barrier function, thereby improving gut health.
肠道是一个特别动态的环境，其中宿主与称为微生物组的数万亿共生细菌不断相互作用。通过群体感应 (QS) 通讯，细菌可以协调它们的社会行为，并以非侵入性的方式影响宿主细胞的活动。如今，大量的研究极大地促进了对细菌 QS 通讯如何调节细菌共生行为的理解，因为共生和宿主-微生物相互作用。在这篇综述中，我们讨论了肠道中的细菌 QS 及其在生物膜形成中的作用。作为生物屏障，黏膜免疫系统可以有效地防止致病微生物和其他免疫原性成分进入宿主的内部环境。我们专注于生物膜与肠道黏膜免疫之间的关系，以及益生菌如何调节它们。这篇综述为开发针对肠道屏障功能的新技术（包括益生菌）提供了理论基础，从而改善肠道健康。
