Li Guo, Zhou Ruyi, Zhao Weili, Yu Bo, Zhou Jie, Liu Shujuan, Huang Wei, Zhao Qiang
Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications (NUPT), 9 Wenyuan Road, Nanjing, 210023 Jiangsu, China.
Frontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an 710072, China.
Research (Wash D C). 2020 Oct 10;2020:5351848. doi: 10.34133/2020/5351848. eCollection 2020.
Hypoxia significantly compromises the therapeutic performance of photodynamic therapy (PDT) owing to the oxygen level which plays a key role in the production of singlet oxygen (O). Herein, the photothermally responsive phase change materials (PCM) are used to encapsulate 1,4-dimethylnaphthalene-functionalized platinum(II)-acetylide conjugated polymer (CP1) with intense near-infrared (NIR) absorption to prepare new O nanocarriers (CP1-NCs). The 1,4-dimethylnaphthalene moieties in CP1-NCs can trap the O produced from CP1 under irradiation and form a stable endoperoxide. Then, the endoperoxide undergoes cycloreversion to controllably release O via the NIR light-triggered photothermal effect of CP1 and controllable phase change of PCM, which can be used for oxygen-independent PDT for hypoxic tumor. Furthermore, the luminescence imaging-guided synergistic PDT and photothermal therapy showed better efficiency in tumor ablation. The smart design shows the potent promise of CP1-NCs in PCM-controlled and sustainable phototherapy under tumor hypoxic microenvironment, providing new insights for constructing oxygen-independent precise cancer phototherapeutic platform.
由于氧气水平在单线态氧(O)的产生中起关键作用,缺氧显著损害了光动力疗法(PDT)的治疗效果。在此,利用光热响应相变材料(PCM)封装具有强烈近红外(NIR)吸收的1,4-二甲基萘官能化铂(II)-乙炔共轭聚合物(CP1),制备新型O纳米载体(CP1-NCs)。CP1-NCs中的1,4-二甲基萘部分可以捕获照射下CP1产生的O并形成稳定的内过氧化物。然后,内过氧化物通过CP1的近红外光触发光热效应和PCM的可控相变进行环反转以可控地释放O,可用于缺氧肿瘤的非氧依赖型PDT。此外,发光成像引导的协同PDT和光热疗法在肿瘤消融方面显示出更好的效率。这种智能设计显示了CP1-NCs在肿瘤缺氧微环境下的PCM控制和可持续光疗中的巨大潜力,为构建非氧依赖型精确癌症光治疗平台提供了新的见解。