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用于缺氧肿瘤的相变控制和可持续光疗的光热响应共轭聚合物单线态氧载体

Photothermally Responsive Conjugated Polymeric Singlet Oxygen Carrier for Phase Change-Controlled and Sustainable Phototherapy for Hypoxic Tumor.

作者信息

Li Guo, Zhou Ruyi, Zhao Weili, Yu Bo, Zhou Jie, Liu Shujuan, Huang Wei, Zhao Qiang

机构信息

Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications (NUPT), 9 Wenyuan Road, Nanjing, 210023 Jiangsu, China.

Frontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an 710072, China.

出版信息

Research (Wash D C). 2020 Oct 10;2020:5351848. doi: 10.34133/2020/5351848. eCollection 2020.

DOI:10.34133/2020/5351848
PMID:33103118
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7569507/
Abstract

Hypoxia significantly compromises the therapeutic performance of photodynamic therapy (PDT) owing to the oxygen level which plays a key role in the production of singlet oxygen (O). Herein, the photothermally responsive phase change materials (PCM) are used to encapsulate 1,4-dimethylnaphthalene-functionalized platinum(II)-acetylide conjugated polymer (CP1) with intense near-infrared (NIR) absorption to prepare new O nanocarriers (CP1-NCs). The 1,4-dimethylnaphthalene moieties in CP1-NCs can trap the O produced from CP1 under irradiation and form a stable endoperoxide. Then, the endoperoxide undergoes cycloreversion to controllably release O via the NIR light-triggered photothermal effect of CP1 and controllable phase change of PCM, which can be used for oxygen-independent PDT for hypoxic tumor. Furthermore, the luminescence imaging-guided synergistic PDT and photothermal therapy showed better efficiency in tumor ablation. The smart design shows the potent promise of CP1-NCs in PCM-controlled and sustainable phototherapy under tumor hypoxic microenvironment, providing new insights for constructing oxygen-independent precise cancer phototherapeutic platform.

摘要

由于氧气水平在单线态氧（O）的产生中起关键作用，缺氧显著损害了光动力疗法（PDT）的治疗效果。在此，利用光热响应相变材料（PCM）封装具有强烈近红外（NIR）吸收的1,4-二甲基萘官能化铂（II）-乙炔共轭聚合物（CP1），制备新型O纳米载体（CP1-NCs）。CP1-NCs中的1,4-二甲基萘部分可以捕获照射下CP1产生的O并形成稳定的内过氧化物。然后，内过氧化物通过CP1的近红外光触发光热效应和PCM的可控相变进行环反转以可控地释放O，可用于缺氧肿瘤的非氧依赖型PDT。此外，发光成像引导的协同PDT和光热疗法在肿瘤消融方面显示出更好的效率。这种智能设计显示了CP1-NCs在肿瘤缺氧微环境下的PCM控制和可持续光疗中的巨大潜力，为构建非氧依赖型精确癌症光治疗平台提供了新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/207d/7569507/76d4a77f881d/RESEARCH2020-5351848.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/207d/7569507/efd2b5000cfb/RESEARCH2020-5351848.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/207d/7569507/59e497d51e63/RESEARCH2020-5351848.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/207d/7569507/e904f01e2906/RESEARCH2020-5351848.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/207d/7569507/aa958d2889a9/RESEARCH2020-5351848.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/207d/7569507/80f6e1f7cac1/RESEARCH2020-5351848.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/207d/7569507/161a5eb919e7/RESEARCH2020-5351848.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/207d/7569507/76d4a77f881d/RESEARCH2020-5351848.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/207d/7569507/efd2b5000cfb/RESEARCH2020-5351848.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/207d/7569507/59e497d51e63/RESEARCH2020-5351848.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/207d/7569507/e904f01e2906/RESEARCH2020-5351848.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/207d/7569507/aa958d2889a9/RESEARCH2020-5351848.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/207d/7569507/80f6e1f7cac1/RESEARCH2020-5351848.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/207d/7569507/161a5eb919e7/RESEARCH2020-5351848.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/207d/7569507/76d4a77f881d/RESEARCH2020-5351848.007.jpg

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