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副肿瘤综合征与SARS-CoV-2——两种血栓形成性疾病的叠加效应?

Paraneoplastic Syndrome and SARS-CoV-2-Incremental Effect of 2 Thrombogenic Conditions?

作者信息

Mangner Norman, Sveric Krunoslav, Gerber Johannes C, Svitil Jan, Linke Axel, Jellinghaus Stefanie

机构信息

Herzzentrum Dresden, Technische Universität Dresden, Department of Internal Medicine and Cardiology, Dresden, Germany.

Neuroradiology, Dresden Neurovascular Center, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

出版信息

CJC Open. 2021 Feb;3(2):217-220. doi: 10.1016/j.cjco.2020.10.010. Epub 2020 Oct 21.

DOI:10.1016/j.cjco.2020.10.010
PMID:33106785
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7577269/
Abstract

We present the case of a patient with a nonbacterial thrombotic aortic valve endocarditis experiencing severe thromboembolic complications and an acute right internal carotid artery occlusion in the context of a paraneoplastic syndrome and an asymptomatic severe acute respiratory syndrome coronavirus-2 infection, despite treatment with different and overlapping anticoagulant medications. Patients with increased thrombogenicity due to an underlying disease might be at increased risk for thrombotic events during a severe acute respiratory syndrome coronavirus-2 infection.

摘要

我们报告了一例非细菌性血栓性主动脉瓣心内膜炎患者的病例,该患者尽管接受了不同且重叠的抗凝药物治疗,但在副肿瘤综合征和无症状的严重急性呼吸综合征冠状病毒2感染的情况下,仍出现了严重的血栓栓塞并发症及急性右颈内动脉闭塞。由于基础疾病导致血栓形成倾向增加的患者,在严重急性呼吸综合征冠状病毒2感染期间发生血栓事件的风险可能会增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12f7/7893192/13e8034a1c99/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12f7/7893192/13e8034a1c99/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12f7/7893192/13e8034a1c99/gr1.jpg

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Therapeutic versus prophylactic anticoagulation for severe COVID-19: A randomized phase II clinical trial (HESACOVID).治疗性与预防性抗凝治疗重症 COVID-19:一项随机 II 期临床试验(HESACOVID)。
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Nonbacterial thrombotic endocarditis in cancer patients: pathogenesis, diagnosis, and treatment.癌症患者的非细菌性血栓性心内膜炎:发病机制、诊断与治疗
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