Department of Physical Medicine, Rehabilitation and Occupational Medicine, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria.
Center for Medical Statistics, Informatics and Intelligent Systems (CeMSIIS), Medical University of Vienna, Vienna, Austria.
Support Care Cancer. 2021 Apr;29(4):1781-1794. doi: 10.1007/s00520-020-05834-x. Epub 2020 Oct 26.
To evaluate the impact of high-intensity interval training (HIIT) on health-related outcome parameters in the prehabilitation of patients diagnosed with cancer.
A systematic review and meta-analysis of comparative studies on HIIT in cancer prehabilitation conducted by screening standard databases from their inception to March 30, 2020. Outcomes of interest included cardiorespiratory fitness, feasibility, safety, clinical, and patient-reported outcomes.
Of the 855 identified studies, 8 articles met the inclusion criteria (7 randomized, 1 non-randomized controlled trial) with a total of 896 patients. The study protocols were heterogeneous, but the methodological quality ranged from good to high according to PEDro scale. Meta-analysis revealed a significant improvement of peak oxygen consumption (VOpeak) achieved with HIIT compared to usual care. Furthermore, HIIT was feasible and safe, showing low risk of adverse events and positive effects on health-related outcomes in prehabilitative settings.
In the phase of prehabilitation, HIIT has potential health benefits in patients diagnosed with cancer and is feasible and safe to perform. Nonetheless, larger randomized controlled trials focusing on long-term effects (such as cancer recurrence or survival rates) are missing, to underline the potential relevance of HIIT for cancer patients.
评估高强度间歇训练（HIIT）对癌症患者康复期相关健康参数的影响。
对 2020 年 3 月 30 日前通过标准数据库筛选的 HIIT 在癌症康复期应用的比较研究进行系统评价和荟萃分析。主要研究结果包括心肺功能、可行性、安全性、临床和患者报告的结果。
在 855 项已确定的研究中，有 8 篇文章符合纳入标准（7 项随机对照试验，1 项非随机对照试验），共纳入 896 例患者。研究方案存在异质性，但根据 PEDro 量表，其方法学质量为良至高度。荟萃分析显示，与常规护理相比，HIIT 可显著提高峰值摄氧量（VOpeak）。此外，HIIT 具有可行性和安全性，在康复期具有低风险的不良事件和对健康相关结果的积极影响。
在康复阶段，HIIT 对癌症患者具有潜在的健康益处，且具有可行性和安全性。然而，目前仍缺乏关注长期效果（如癌症复发或生存率）的大型随机对照试验，这突出了 HIIT 对癌症患者的潜在重要性。
