Department of Science, Dong Nai University, Bien Hoa City, Vietnam.
Department of Chemistry, University of Science, National University-HCM City, Ho Chi Minh City, Vietnam.
Nat Prod Res. 2022 Apr;36(8):1934-1940. doi: 10.1080/14786419.2020.1837818. Epub 2020 Oct 27.
Three new diphenyl ethers, named praesorethers E, F and G (, and ), were isolated from the lichen . Their chemical structures were elucidated on the basis of extensively spectroscopic analysis including HR-ESI-MS and NMR as well as comparison with previously published data. These compounds were evaluated for the cytotoxicity against three human cancer cell lines (HeLa, NCI-H460 and MCF-7) using SRB assay. As results, and exhibited weak cytotoxic activity against three tested cancer cell lines with the inhibitive percentage of 64-79.9% at the concentration of 100 μg/mL while was inactive.
三种新的二苯醚，命名为 praesorethers E、F 和 G（、和），从地衣中分离得到。基于广泛的光谱分析，包括高分辨电喷雾电离质谱和 NMR 以及与已发表数据的比较，确定了它们的化学结构。采用 SRB 法评价了这些化合物对三种人癌细胞系（HeLa、NCI-H460 和 MCF-7）的细胞毒性。结果表明，和对三种测试的癌细胞系具有较弱的细胞毒性活性，在 100μg/ml 的浓度下抑制率为 64-79.9%，而则没有活性。
