从地衣 (Nyl.) Hale (Parmeliaceae) 中分离得到的三种新的二苯醚。
Three new diphenyl ethers from the lichen (Nyl.) Hale (Parmeliaceae).
机构信息
Department of Science, Dong Nai University, Bien Hoa City, Vietnam.
Department of Chemistry, University of Science, National University-HCM City, Ho Chi Minh City, Vietnam.
出版信息
Nat Prod Res. 2022 Apr;36(8):1934-1940. doi: 10.1080/14786419.2020.1837818. Epub 2020 Oct 27.
Three new diphenyl ethers, named praesorethers E, F and G (, and ), were isolated from the lichen . Their chemical structures were elucidated on the basis of extensively spectroscopic analysis including HR-ESI-MS and NMR as well as comparison with previously published data. These compounds were evaluated for the cytotoxicity against three human cancer cell lines (HeLa, NCI-H460 and MCF-7) using SRB assay. As results, and exhibited weak cytotoxic activity against three tested cancer cell lines with the inhibitive percentage of 64-79.9% at the concentration of 100 μg/mL while was inactive.
三种新的二苯醚，命名为 praesorethers E、F 和 G（、和），从地衣中分离得到。基于广泛的光谱分析，包括高分辨电喷雾电离质谱和 NMR 以及与已发表数据的比较，确定了它们的化学结构。采用 SRB 法评价了这些化合物对三种人癌细胞系（HeLa、NCI-H460 和 MCF-7）的细胞毒性。结果表明，和对三种测试的癌细胞系具有较弱的细胞毒性活性，在 100μg/ml 的浓度下抑制率为 64-79.9%，而则没有活性。
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