Do Thanh-Hung, Duong Thuc-Huy, Nguyen Minh An Tran, Vo Thi-Phi-Giao, Do Van-Mai, Nguyen Ngoc-Hong, Sichaem Jirapast
NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City, 754000, Vietnam.
Department of Chemistry, Ho Chi Minh City University of Education, 280 An Duong Vuong Street, District 5, Ho Chi Minh City, 700000, Vietnam.
Chem Biodivers. 2023 Mar;20(3):e202201213. doi: 10.1002/cbdv.202201213. Epub 2023 Mar 8.
A bioactivity-guided investigation of the lichen Parmotrema cristiferum (Taylor) Hale (Parmeliaceae) led to the isolation of two new depsidones, cristifones A and B (1 and 2). The structures of the isolated compounds were identified by spectroscopic methods and comparison with the literature data. Compound 1 showed the initial combined structures of depsidone and depside cores. The two isolated compounds were then evaluated for α-glucosidase inhibition. Compounds 1 and 2 were confirmed as potent, with IC values of 21.5 and 18.4 μM, respectively. Compound 2 was a non-competitive inhibitor against α-glucosidase, as indicated by the intersect in the second quadrant of each respective plot.
对地衣石耳（Taylor）Hale（梅衣科）进行生物活性导向研究，分离得到两种新的缩酚酸环醚酮，石耳素A和B（1和2）。通过光谱方法并与文献数据比较确定了分离出的化合物的结构。化合物1显示出缩酚酸环醚酮和缩酚酸核心的初始组合结构。然后评估了这两种分离出的化合物对α-葡萄糖苷酶的抑制作用。化合物1和2被确认为具有强效抑制作用，其IC值分别为21.5和18.4 μM。如各自图的第二象限中的交点所示，化合物2是α-葡萄糖苷酶的非竞争性抑制剂。
