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帕雷索丁 A,一种来自地衣的新型二苯环状过氧化物。

Paresordin A, a new diphenyl cyclic peroxide from the lichen .

机构信息

Department of Science, Dong Nai University, 04 Le Quy Don, Bien Hoa City, Dong Nai Province 760000, Vietnam.

Faculty of Environmental Science, Sai Gon University, 273 An Duong Vuong, Ho Chi Minh City 700000, Vietnam.

出版信息

J Asian Nat Prod Res. 2022 Feb;24(2):190-195. doi: 10.1080/10286020.2021.1908271. Epub 2021 Apr 1.

Abstract

From the lichen Parmotrema praesorediosum, one new diphenyl peroxide, named praesordin A (1), together with four depsidones, including virensic acid (), protocetraric acid (), 8'--methylprotocetraric acid (), and furfuric acid () were purified. Their structures were chacracterized using extensive HR-ESI-MS and NMR spectroscopic methods. The isolated compounds () possessed stronger -glucosidase inhibitory activity (IC = 43.7-110.1 μM) than the standard drug acarbose (IC = 214.5 μM).

摘要

从地衣 Parmotrema praesorediosum 中分离得到一种新的二苯过氧化物,命名为 praesordin A(1),以及四种去甲二萜酮,包括 virensic acid()、protocetraric acid()、8'--methylprotocetraric acid()和 furfuric acid()。它们的结构通过 HR-ESI-MS 和 NMR 光谱方法进行了表征。分离得到的化合物()比标准药物阿卡波糖(IC = 214.5 μM)具有更强的 -葡萄糖苷酶抑制活性(IC = 43.7-110.1 μM)。

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