一种与哺乳动物胃动素结构相关的胰高血糖素样肽，来自全头亚纲鱼类银鲛的胰腺。
A glucagon-like peptide, structurally related to mammalian oxyntomodulin, from the pancreas of a holocephalan fish, Hydrolagus colliei.
作者信息
Conlon J M, Dafgård E, Falkmer S, Thim L
机构信息
Clinical Research Group for Gastrointestinal Endocrinology, Max-Planck-Society, University of Göttingen, Federal Republic of Germany.
出版信息
Biochem J. 1987 Aug 1;245(3):851-5. doi: 10.1042/bj2450851.
The pancreatic islets of the holocephalan fishes contain, in addition to A-, B- and D-cells, X-cells, which are immunoreactive towards antisera directed against the N-terminal region of glucagon but not towards antisera directed against the C-terminal region. A 36-amino-acid-residue peptide was isolated from the pancreas of a holocephalan fish, the Pacific ratfish (Hydrolagus colliei), that shows homology (69%) to mammalian glucagon in its N-terminal region and is reactive towards an N-terminally directed antiserum. Reactivity towards C-terminally directed antisera is prevented by the presence of a 7-residue C-terminal extension to the glucagon sequence that shows limited homology to the C-terminal region of glucagon-37 (oxyntomodulin). It is proposed that this peptide represents a major storage product of the islet X-cell.
全头亚纲鱼类的胰岛除了含有A细胞、B细胞和D细胞外，还含有X细胞，这些X细胞对针对胰高血糖素N端区域的抗血清有免疫反应，但对针对C端区域的抗血清没有免疫反应。从一种全头亚纲鱼类——太平洋兔银鲛（Hydrolagus colliei）的胰腺中分离出一种36个氨基酸残基的肽，该肽在其N端区域与哺乳动物胰高血糖素具有同源性（69%），并且对N端定向抗血清有反应。胰高血糖素序列的C端有一个7个残基的延伸，该延伸与胰高血糖素-37（胃泌酸调节素）的C端区域有有限的同源性，这阻止了对C端定向抗血清的反应。有人提出，这种肽代表胰岛X细胞的主要储存产物。
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