Roosdiana Anna, Permata Fajar Shodiq, Fitriani Riera Indah, Umam Khairul, Safitri Anna
Chemistry Department, Brawijaya University, Jl. Veteran, Malang, 65145, Indonesia.
Faculty of Veterinary Medicine, Brawijaya University, Puncak Dieng Ekslusif, Malang, 65151, Indonesia.
Vet Med Int. 2020 Oct 14;2020:8812758. doi: 10.1155/2020/8812758. eCollection 2020.
is a therapeutic plant that is generally consumed in Indonesian traditional medicine to prevent or cure various illnesses, i.e., diabetes. The current study was conducted to investigate the effects of hydroethanolic root extracts of on the kidney of streptozotocin-induced diabetic Wistar rats. In this study, male Wistar rats were divided into 5 groups: healthy rats (group 1), diabetic rats (group 2), and treated rats which received extract at dosages of 250 (group 3), 375 (group 4), and 500 (group 5) mg/kg body weight for 21 days. Diabetes mellitus was experimentally induced by the administration of five doses of streptozotocin 20 mg/kg body weight within five consecutive days. Significant increases in the value of TNF alpha expression and malondialdehyde (MDA) levels were observed in streptozotocin-induced diabetes rats. Furthermore, severe histological alterations of kidney tissues occurred in the diabetic rats group. After treatment was applied, the value of TNF alpha expression and MDA levels on the kidney decreased considerably ( < 0.05) in groups 3, 4, and 5. The optimum dosage was obtained at a dose of 250 mg/kg body weight (group 3), which had 42.24% and 52.70% decrease in TNF alpha expression and MDA levels, respectively. The histopathological profiles of the kidney also showed significant improvements in treated groups. The most prominent recoveries were also shown in group 3. The treatments induced repairment in the glomerular and renal tubular damages in the kidney tissues. To conclude, these results emphasize potentially health valuable properties of hydroethanolic root extracts of . in rats with streptozotocin-induced diabetes.
是一种治疗性植物，在印度尼西亚传统医学中通常用于预防或治疗各种疾病，如糖尿病。本研究旨在调查[植物名称]水乙醇根提取物对链脲佐菌素诱导的糖尿病Wistar大鼠肾脏的影响。在本研究中，雄性Wistar大鼠分为5组：健康大鼠（第1组）、糖尿病大鼠（第2组）以及接受250（第3组）、375（第4组）和500（第5组）mg/kg体重提取物治疗21天的大鼠。连续五天给予五剂20 mg/kg体重的链脲佐菌素，实验性诱导糖尿病。在链脲佐菌素诱导的糖尿病大鼠中，观察到肿瘤坏死因子α（TNF alpha）表达值和丙二醛（MDA）水平显著升高。此外，糖尿病大鼠组肾脏组织出现严重的组织学改变。治疗后，第3、4和5组肾脏中TNF alpha表达值和MDA水平显著降低（P<0.05）。在250 mg/kg体重剂量（第3组）时获得最佳剂量，该组TNF alpha表达和MDA水平分别下降了42.24%和52.70%。肾脏的组织病理学特征在治疗组中也显示出显著改善。第3组也显示出最显著的恢复。这些治疗诱导了肾脏组织中肾小球和肾小管损伤的修复。总之，这些结果强调了[植物名称]水乙醇根提取物对链脲佐菌素诱导的糖尿病大鼠具有潜在的健康有益特性。
