Al-Naamani Khalid, Al-Hashami Zamzam, Al-Siyabi Omar, Al-Moundri Mansour, Al-Bahrani Bassim, Al-Sinani Siham, Al-Zakwani Ibrahim, Omar Heba, Al-Busafi Said A, Al-Zuhaibi Haifa, AlMamari Abdullah, Kamath Bola R, Al-Kalbani Abdullah, Burney Ikram Ali
Department of Internal Medicine, Armed Forces Hospital, Muscat, Oman.
Department of Medicine, Sultan Qaboos University Hospital, Muscat, Oman.
Sultan Qaboos Univ Med J. 2020 Aug;20(3):e316-e322. doi: 10.18295/squmj.2020.20.03.011. Epub 2020 Oct 5.
Hepatocellular carcinoma (HCC) is the most common type of primary liver tumour worldwide and is increasing in incidence. This study aimed to describe the clinical characteristics of HCC among Omani patients, along with its major risk factors, outcomes and the role of surveillance.
This retrospective case-series study was conducted between January 2008 and December 2015 at the three main tertiary care hospitals in Oman. All adult Omani patients diagnosed with HCC and visited these hospitals during the study period were included. Relevant data were collected from the patients' electronic medical records.
A total of 284 HCC patients were included in the analysis. The mean age was 61.02 ± 11.41 years and 67.6% were male. The majority had liver cirrhosis (79.9%), with the most common aetiologies being chronic hepatitis C (46.5%) and B (43.2%). Only 13.7% of cases were detected by the HCC surveillance programme. Approximately half of the patients (48.5%) had a single liver lesion and 31.9% had a liver tumour of >5 cm in size. Approximately half (49.2%) had alpha-fetoprotein levels of ≥200 ng/mL. The majority (72.5%) were diagnosed using multiphase computed tomography alone. Less than half of the patients (48.9%) were offered one or more HCC treatment modalities.
The majority of Omani HCC patients were male and had cirrhosis due to viral hepatitis. In addition, few patients were identified by the national surveillance programme and presented with advanced disease precluding therapeutic or even palliative treatment.
肝细胞癌（HCC）是全球最常见的原发性肝脏肿瘤类型，且发病率呈上升趋势。本研究旨在描述阿曼患者中HCC的临床特征、主要危险因素、预后情况以及监测的作用。
本回顾性病例系列研究于2008年1月至2015年12月在阿曼的三家主要三级医疗机构进行。纳入所有在研究期间被诊断为HCC并就诊于这些医院的成年阿曼患者。从患者的电子病历中收集相关数据。
共有284例HCC患者纳入分析。平均年龄为61.02±11.41岁，67.6%为男性。大多数患者有肝硬化（79.9%），最常见的病因是慢性丙型肝炎（46.5%）和慢性乙型肝炎（43.2%）。仅13.7%的病例通过HCC监测计划被检测到。约一半的患者（48.5%）有单个肝脏病灶，31.9%的患者肝脏肿瘤大小>5 cm。约一半（49.2%）的患者甲胎蛋白水平≥200 ng/mL。大多数患者（72.5%）仅通过多期计算机断层扫描被诊断。不到一半的患者（48.9%）接受了一种或多种HCC治疗方式。
大多数阿曼HCC患者为男性，且因病毒性肝炎导致肝硬化。此外，通过国家监测计划识别出的患者较少，且呈现出晚期疾病，无法进行治疗甚至姑息治疗。
