DGIST-ETH Microrobot Research Center (DEMRC), Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, South Korea.
Department of Robotics Engineering, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, 42988, South Korea.
Adv Healthc Mater. 2021 Jan;10(2):e2001096. doi: 10.1002/adhm.202001096. Epub 2020 Oct 27.
Microrobots for targeted drug delivery are of great interest due to their minimal invasiveness and wireless controllability. Here, a magnetically driven porous degradable microrobot (PDM) is reported that consists of a 3D printed helical soft polymeric chassis made of a poly(ethylene glycol) diacrylate and pentaerythritol triacrylate matrix containing magnetite nanoparticles and the anticancer drug 5-fluorouracil (5-FU). The encapsulated Fe O nanoparticles render the PDM a precise wireless magnetic actuation by means of rotating magnetic fields (RMFs). The increased surface area of the porous PDM facilitates the acoustically induced drug release due to a higher response to the acoustic energy. The drug release profile from the PDM can be selected on command from three different modes, referred to herein as natural, burst, and constant, by differentiating the ultrasound exposure condition. Finally, in vitro test results reveal different therapeutic results for each release mode. The observed great reduction of cancer cell viability in the burst- and constant-release modes confirms that ultrasound with the proposed PDM can enhance the therapeutic effect by increasing drug concentration and sonoporation.
由于其微创性和无线可控性，用于靶向药物输送的微机器人引起了极大的关注。在这里，报道了一种由 3D 打印的螺旋软聚合物底盘组成的磁驱动多孔可降解微机器人（PDM），该底盘由聚乙二醇二丙烯酸酯和季戊四醇三丙烯酸酯基质组成，其中含有磁铁矿纳米颗粒和抗癌药物 5-氟尿嘧啶（5-FU）。封装的 Fe3O4 纳米颗粒通过旋转磁场（RMFs）使 PDM 能够精确地进行无线磁驱动。多孔 PDM 的增加的表面积由于对声能的更高响应而促进了声控药物释放。通过区分超声暴露条件，可以从三种不同模式（本文称为自然、爆发和恒定）中按需选择 PDM 的药物释放曲线。最后，体外测试结果表明，每种释放模式都有不同的治疗效果。在爆发和恒释模式下观察到的癌细胞活力的大幅降低证实了通过增加药物浓度和声穿孔，使用所提出的 PDM 的超声可以增强治疗效果。
