Department of Robotics Engineering, DGIST-ETH Microrobot Research Center, Daegu Gyeongbuk Institute of Science and Technology (DGIST), 333, Techno jungang-daero, Hyeonpung-Myeon, Dalseong-Gun, Daegu, 42988, Republic of Korea.
Adv Healthc Mater. 2019 Aug;8(16):e1900213. doi: 10.1002/adhm.201900213. Epub 2019 Jul 10.
Microrobots facilitate targeted therapy due to their small size, minimal invasiveness, and precise wireless control. A degradable hyperthermia microrobot (DHM) with a 3D helical structure is developed, enabling actively controlled drug delivery, release, and hyperthermia therapy. The microrobot is made of poly(ethylene glycol) diacrylate (PEGDA) and pentaerythritol triacrylate (PETA) and contains magnetic Fe O nanoparticles (MNPs) and 5-fluorouracil (5-FU). Its locomotion is remotely and precisely controlled by a rotating magnetic field (RMF) generated by an electromagnetic actuation system. Drug-free DHMs reduce the viability of cancer cells by elevating the temperature under an alternating magnetic field (AMF), a hyperthermic effect. 5-FU is released from the proposed DHMs in normal-, high-burst-, and constant-release modes, controlled by the AMF. Finally, actively controlled drug release from the DHMs in normal- and high-burst-release mode results in a reduction in cell viability. The reduction in cell viability is of greater magnitude in high-burst- than in normal-release mode. In summary, biodegradable DHMs have potential for actively controlled drug release and hyperthermia therapy.
微机器人由于其体积小、侵入性小和精确的无线控制而有助于靶向治疗。开发了一种具有 3D 螺旋结构的可降解热疗微机器人 (DHM)，能够主动控制药物输送、释放和热疗。微机器人由聚乙二醇二丙烯酸酯 (PEGDA) 和季戊四醇三丙烯酸酯 (PETA) 制成，含有磁性 FeO 纳米粒子 (MNPs) 和 5-氟尿嘧啶 (5-FU)。其运动通过电磁致动系统产生的旋转磁场 (RMF) 进行远程和精确控制。无药物的 DHM 通过在交变磁场 (AMF) 下升高温度来降低癌细胞的活力，从而产生热疗效果。5-FU 从所提出的 DHM 中以正常、高突发和恒速释放模式释放，受 AMF 控制。最后，DHM 在正常和高突发释放模式下的主动控制药物释放导致细胞活力降低。在高突发释放模式下，细胞活力的降低幅度大于正常释放模式。总之，可生物降解的 DHM 具有主动控制药物释放和热疗的潜力。
