College of Pharmacy, Dongguk University, Seoul 04620, Korea.
Cells. 2020 Oct 25;9(11):2352. doi: 10.3390/cells9112352.
Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate. Accumulating evidence has noted that FDFT1 plays a critical role in cancer, particularly in metabolic reprogramming, cell proliferation, and invasion. Based on these advances in our knowledge, FDFT1 could be a potential target for cancer treatment. This review focuses on the contribution of FDFT1 to the hallmarks of cancer, and further, we discuss the applicability of FDFT1 as a cancer prognostic marker and target for anticancer therapy.
法呢基二磷酸法呢基转移酶 1（FDFT1，鲨烯合酶）是一种膜相关酶，通过缩合两个法呢基焦磷酸分子合成鲨烯。越来越多的证据表明，FDFT1 在癌症中起着关键作用，特别是在代谢重编程、细胞增殖和侵袭方面。基于我们在这方面知识的进步，FDFT1 可能成为癌症治疗的一个潜在靶点。本综述重点讨论了 FDFT1 对癌症特征的贡献，进一步探讨了 FDFT1 作为癌症预后标志物和抗癌治疗靶点的适用性。
