Naskar Atanu, Kim Kwang-Sun
Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241, Korea.
Pharmaceutics. 2021 Jan 11;13(1):86. doi: 10.3390/pharmaceutics13010086.
Bacteriocins are antimicrobial peptides or proteinaceous materials produced by bacteria against pathogens. These molecules have high efficiency and specificity and are equipped with many properties useful in food-related applications, such as food preservatives and additives, as well as biomedical applications, such as serving as alternatives to current antibacterial, antiviral, anticancer, and antibiofilm agents. Despite their advantages as alternative therapeutics over existing strategies, several limitations of bacteriocins, such as the high cost of isolation and purification, narrow spectrum of activity, low stability and solubility, and easy enzymatic degradation, need to be improved. Nanomaterials are promising agents in many biological applications. They are widely used in the conjugation or decoration of bacteriocins to augment the activity of bacteriocins or reduce problems related to their use in biomedical applications. Therefore, bacteriocins combined with nanomaterials have emerged as promising molecules that can be used in various biomedical applications. This review highlights the features of bacteriocins and their limitations in biomedical applications and provides a detailed overview of the uses of different nanomaterials in improving the limitations. Our review focuses on the potential applications of nanomaterials combined with bacteriocins as new designer molecules for use in future therapeutic strategies.
细菌素是细菌产生的对抗病原体的抗菌肽或蛋白质类物质。这些分子具有高效性和特异性，并具备许多在食品相关应用（如食品防腐剂和添加剂）以及生物医学应用（如作为当前抗菌、抗病毒、抗癌和抗生物膜剂的替代品）中有用的特性。尽管细菌素作为现有策略的替代疗法具有优势，但细菌素存在一些局限性，如分离和纯化成本高、活性谱窄、稳定性和溶解性低以及易被酶降解等，这些都需要改进。纳米材料在许多生物应用中是有前景的试剂。它们被广泛用于细菌素的共轭或修饰，以增强细菌素的活性或减少其在生物医学应用中使用时的相关问题。因此，细菌素与纳米材料结合已成为可用于各种生物医学应用的有前景的分子。本综述强调了细菌素的特性及其在生物医学应用中的局限性，并详细概述了不同纳米材料在改善这些局限性方面的用途。我们的综述重点关注纳米材料与细菌素结合作为新型设计分子在未来治疗策略中的潜在应用。
