Youssef Fady Sayed, El-Banna Hossny Awad, Elzorba Hesham Youssef, Galal Ahmed Mohamed
Pharmacology department, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Int J Vet Sci Med. 2019 Dec 26;7(1):78-93. doi: 10.1080/23144599.2019.1691379. eCollection 2019.
Nanotechnology is a fast-growing technology that plays an important great impact on various fields of therapeutic applications. It is capable for solving several problems related to animal health and production. There are different nano-systems such as liposomes, metallic nanoparticles, polymeric micelles, polymeric nanospheres, functionalized fullerenes, carbon nanotubes, dendrimers, polymer-coated nanocrystals and nanoshells. In this review, we mentioned different methods for the preparation and characterization of nanoparticles. This review is concerned mainly on nanoparticle systems for antibiotic delivery which suffer from poor bioavailability and many side effects. Nanoparticles are characterized by many features include their minimal size, colossal surface zone to mass extent. The development of antimicrobials in nanoparticle systems is considered an excellent alternative delivery system for antimicrobials for the treatment of microbial diseases by increasing therapeutic effect and overcoming the side effects. In this paper, we reviewed some antimicrobial nanoparticle preparations and we focused on florfenicol and neomycin nanoparticle preparations as well as chitosan and silver nanoparticles preparations to prepare, characterize and compare their different pharmacological effects.
纳米技术是一种快速发展的技术，对治疗应用的各个领域都产生了重大影响。它能够解决与动物健康和生产相关的几个问题。有不同的纳米系统，如脂质体、金属纳米颗粒、聚合物胶束、聚合物纳米球、功能化富勒烯、碳纳米管、树枝状大分子、聚合物包覆的纳米晶体和纳米壳。在这篇综述中，我们提到了制备和表征纳米颗粒的不同方法。这篇综述主要关注用于抗生素递送的纳米颗粒系统，该系统存在生物利用度差和许多副作用的问题。纳米颗粒具有许多特征，包括其最小尺寸、巨大的表面积与质量比。纳米颗粒系统中抗菌剂的开发被认为是一种极好的抗菌剂替代递送系统，可通过提高治疗效果和克服副作用来治疗微生物疾病。在本文中，我们综述了一些抗菌纳米颗粒制剂，并重点关注氟苯尼考和新霉素纳米颗粒制剂以及壳聚糖和银纳米颗粒制剂，以制备、表征和比较它们不同的药理作用。
