Vannella Kevin M, Stein Sydney, Connelly Mark, Swerczek Joanna, Amaro-Carambot Emerito, Coyle Elizabeth M, Babyak Ashley, Winkler Clayton W, Saturday Greg, Gai Neville D, Hammoud Dima A, Dowd Kimberly A, Valencia Luis Perez, Ramos-Benitez Marcos J, Kindrachuk Jason, Pierson Theodore C, Peterson Karin E, Brenchley Jason M, Whitehead Steve S, Khurana Surender, Herbert Richard, Chertow Daniel S
Emerging Pathogens Section, Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA.
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Sci Transl Med. 2020 Oct 28;12(567). doi: 10.1126/scitranslmed.aaz4997.
There is limited information about the impact of Zika virus (ZIKV) exposure in utero on the anti-ZIKV immune responses of offspring. We infected six rhesus macaque dams with ZIKV early or late in pregnancy and studied four of their offspring over the course of a year postpartum. Despite evidence of ZIKV exposure in utero, we observed no structural brain abnormalities in the offspring. We detected infant-derived ZIKV-specific immunoglobulin A antibody responses and T cell memory responses during the first year postpartum in the two offspring born to dams infected with ZIKV early in pregnancy. Critically, although the infants had acquired some immunological memory of ZIKV, it was not sufficient to protect them against reinfection with ZIKV at 1 year postpartum. The four offspring reexposed to ZIKV at 1 year postpartum all survived but exhibited acute viremia and viral tropism to lymphoid tissues; three of four reexposed offspring exhibited spinal cord pathology. These data suggest that macaque infants born to dams infected with ZIKV during pregnancy remain susceptible to postnatal infection and consequent neuropathology.
关于子宫内接触寨卡病毒（ZIKV）对后代抗寨卡病毒免疫反应的影响，目前信息有限。我们在怀孕早期或晚期用寨卡病毒感染了六只恒河猴母猴，并在产后一年的时间里对它们的四只后代进行了研究。尽管有子宫内接触寨卡病毒的证据，但我们在后代中未观察到结构性脑异常。我们在怀孕早期感染寨卡病毒的母猴所生的两只后代产后第一年检测到了婴儿来源的寨卡病毒特异性免疫球蛋白A抗体反应和T细胞记忆反应。至关重要的是，尽管婴儿获得了一些寨卡病毒的免疫记忆，但这不足以在产后1年保护他们免受寨卡病毒的再次感染。产后1年再次接触寨卡病毒的四只后代均存活，但表现出急性病毒血症和对淋巴组织的病毒嗜性；四只再次接触病毒的后代中有三只出现脊髓病变。这些数据表明，怀孕期间感染寨卡病毒的母猴所生的猕猴婴儿在出生后仍易受感染并因此出现神经病理学变化。
