中重度慢性肾脏病患者颈动脉最大内膜中层厚度变化的相关因素
Factors Associated with the Change in Carotid Maximum Intima-Media Thickness in Patients with Moderate-to-Advanced Stage Chronic Kidney Disease.
作者信息
Hirai Keiji, Morino Junki, Minato Saori, Kaneko Shohei, Yanai Katsunori, Mutsuyoshi Yuko, Ishii Hiroki, Matsuyama Momoko, Kitano Taisuke, Aomatsu Akinori, Miyazawa Haruhisa, Ito Kiyonori, Ueda Yuichiro, Ookawara Susumu, Morishita Yoshiyuki
机构信息
Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
出版信息
Diabetes Metab Syndr Obes. 2020 Oct 12;13:3637-3643. doi: 10.2147/DMSO.S267533. eCollection 2020.
PURPOSE
The objective of this study was to determine factors associated with the change in carotid maximum intima-media thickness (IMT), an established surrogate marker of atherosclerosis, in moderate-to-advanced stage chronic kidney disease (CKD) patients.
METHODS
In total, 130 moderate-to-advanced stage CKD patients (mean age: 67.6 ± 11.0 years old; 91 men and 39 women) were included in this retrospective, single-center, observational study. Relationships between the change in carotid maximum IMT and clinical and laboratory data were analyzed by using multivariate linear regression analyses.
RESULTS
Mean observation period was 2.9 ± 1.6 years. Mean carotid maximum IMT at baseline was 2.2 ± 1.0 mm, and the annual change in carotid maximum IMT was 0.06 ± 0.22 mm/year. Low-density lipoprotein (LDL)-cholesterol (β = 0.173, p < 0.05) and annual change in triglyceride (β = 0.175, p < 0.05) independently correlated with the annual change in carotid maximum IMT.
CONCLUSION
Increases in LDL-cholesterol and triglyceride were associated with the rate of progression of carotid maximum IMT in moderate-to-advanced stage CKD patients.
目的
本研究的目的是确定中晚期慢性肾脏病（CKD）患者中，与颈动脉最大内膜中层厚度（IMT）变化相关的因素，颈动脉最大IMT是动脉粥样硬化的既定替代标志物。
方法
本项回顾性、单中心观察性研究共纳入130例中晚期CKD患者（平均年龄：67.6±11.0岁；男性91例，女性39例）。采用多元线性回归分析颈动脉最大IMT变化与临床及实验室数据之间的关系。
结果
平均观察期为2.9±1.6年。基线时颈动脉最大IMT平均值为2.2±1.0mm，颈动脉最大IMT的年变化为0.06±0.22mm/年。低密度脂蛋白（LDL）胆固醇（β = 0.173，p < 0.05）和甘油三酯的年变化（β = 0.175，p < 0.05）与颈动脉最大IMT的年变化独立相关。
结论
中晚期CKD患者中，LDL胆固醇和甘油三酯的升高与颈动脉最大IMT的进展速度相关。
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