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Androgen regulation of pulmonary AR, TMPRSS2 and ACE2 with implications for sex-discordant COVID-19 outcomes.雄激素对肺内 AR、TMPRSS2 和 ACE2 的调节作用及其对性别差异 COVID-19 结局的影响。
Sci Rep. 2021 May 27;11(1):11130. doi: 10.1038/s41598-021-90491-1.
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Single-Cell RNA Expression Profiling of ACE2, the Receptor of SARS-CoV-2.新型冠状病毒(SARS-CoV-2)受体ACE2的单细胞RNA表达谱分析
Am J Respir Crit Care Med. 2020 Sep 1;202(5):756-759. doi: 10.1164/rccm.202001-0179LE.
3
Negative impact of hyperglycaemia on tocilizumab therapy in Covid-19 patients.高血糖对 COVID-19 患者托珠单抗治疗的负面影响。
Diabetes Metab. 2020 Oct;46(5):403-405. doi: 10.1016/j.diabet.2020.05.005. Epub 2020 May 21.
4
Joint HFSA/ACC/AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID-19.美国心力衰竭学会/美国心脏病学会/美国心脏协会联合声明回应关于在2019冠状病毒病中使用肾素-血管紧张素-醛固酮系统拮抗剂的担忧。
J Card Fail. 2020 May;26(5):370. doi: 10.1016/j.cardfail.2020.04.013.
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Pharmacological characteristics of patients infected with SARS-Cov-2 admitted to Intensive Care Unit in South of France.法国南部重症监护病房收治的感染新型冠状病毒肺炎患者的药理学特征。
Therapie. 2020 Jul-Aug;75(4):381-384. doi: 10.1016/j.therap.2020.05.005. Epub 2020 May 15.
6
ACEI/ARB use and risk of infection or severity or mortality of COVID-19: A systematic review and meta-analysis.血管紧张素转换酶抑制剂/血管紧张素Ⅱ受体拮抗剂的使用与 COVID-19 感染或严重程度或死亡率风险:系统评价和荟萃分析。
Pharmacol Res. 2020 Aug;158:104927. doi: 10.1016/j.phrs.2020.104927. Epub 2020 May 15.
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Risks and Impact of Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers on SARS-CoV-2 Infection in Adults: A Living Systematic Review.血管紧张素转换酶抑制剂或血管紧张素受体阻滞剂对成人 SARS-CoV-2 感染的风险和影响:一项实时系统评价。
Ann Intern Med. 2020 Aug 4;173(3):195-203. doi: 10.7326/M20-1515. Epub 2020 May 15.
8
Use of renin-angiotensin-aldosterone system inhibitors and risk of COVID-19 requiring admission to hospital: a case-population study.血管紧张素转换酶抑制剂和血管紧张素受体阻滞剂与 COVID-19 住院风险的相关性:一项基于病例的队列研究
Lancet. 2020 May 30;395(10238):1705-1714. doi: 10.1016/S0140-6736(20)31030-8. Epub 2020 May 14.
9
Practical recommendations for the management of diabetes in patients with COVID-19.关于 COVID-19 患者糖尿病管理的实用建议。
Lancet Diabetes Endocrinol. 2020 Jun;8(6):546-550. doi: 10.1016/S2213-8587(20)30152-2. Epub 2020 Apr 23.
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Severe COVID-19 during Pregnancy and Possible Vertical Transmission.孕妇严重 COVID-19 病例及可能的垂直传播。
Am J Perinatol. 2020 Jun;37(8):861-865. doi: 10.1055/s-0040-1710050. Epub 2020 Apr 18.

2019冠状病毒病大流行期间糖尿病女性面临的挑战

Challenges in Women with Diabetes During the COVID-19 Pandemic.

作者信息

Priya Gagan, Bajaj Sarita, Grewal Emmy, Maisnam Indira, Chandrasekharan Sruti, Selvan Chitra

机构信息

Department of Endocrinology, Fortis and Ivy Hospitals, Mohali, Punjab, India.

Department of Medicine, Moti Lal Nehru Medical College, Prayagraj, Uttar Pradesh, India.

出版信息

Eur Endocrinol. 2020 Oct;16(2):100-108. doi: 10.17925/EE.2020.16.2.100. Epub 2020 Oct 6.

DOI:10.17925/EE.2020.16.2.100
PMID:33117440
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7572165/
Abstract

The coronavirus disease 2019 (COVID-19) pandemic has created significant challenges for healthcare systems across the world. The disease seems to infect men and women in equal numbers, though trends suggest that men have greater morbidity. This has been attributed to differences in immunological response, expression of angiotensin-converting enzyme 2 (ACE2), prevalence of comorbidities, and health-related behaviours, such as smoking. However, this cannot be taken to mean that women are somehow protected. Advanced age, smoking, diabetes, hypertension, cardiovascular disease and chronic obstructive pulmonary disease have emerged as the leading contributors to increased morbidity and mortality from the disease. Women with diabetes form a vulnerable group as they often receive suboptimal diabetes care and support, even though they have a high burden of comorbidities and complications. While there are challenges in healthcare delivery during the pandemic, cardiometabolic care cannot be compromised, which calls for exploring new avenues of healthcare delivery, such as telemedicine. Pregnant women with diabetes should continue to receive quality care for optimal outcomes, and the psychological health of women also needs special consideration. The management of hyperglycaemia during COVID-19 infection is important to reduce morbidity and mortality from the infection. The gendered impact of outbreaks and quarantine goes beyond biomedical and psychological aspects, and the socioeconomic impact of the pandemic is likely to affect the long-term care of women with diabetes, which creates an urgent need to create effective policies and interventions to promote optimal care in this vulnerable group.

摘要

2019年冠状病毒病(COVID-19)大流行给全球医疗系统带来了巨大挑战。该疾病似乎对男性和女性的感染人数相当,不过有趋势表明男性的发病率更高。这归因于免疫反应、血管紧张素转换酶2(ACE2)表达、合并症患病率以及吸烟等与健康相关行为的差异。然而,这并不意味着女性受到了某种程度的保护。高龄、吸烟、糖尿病、高血压、心血管疾病和慢性阻塞性肺疾病已成为该疾病发病率和死亡率上升的主要因素。患有糖尿病的女性构成了一个弱势群体,因为尽管她们合并症和并发症负担沉重,但往往得到的糖尿病护理和支持并不理想。虽然在大流行期间医疗服务提供存在挑战,但心脏代谢护理不能受到影响,这就需要探索新的医疗服务提供途径,如远程医疗。患有糖尿病的孕妇应继续接受优质护理以实现最佳结局,女性的心理健康也需要特别关注。COVID-19感染期间高血糖的管理对于降低感染导致的发病率和死亡率很重要。疫情爆发和隔离对性别的影响不仅限于生物医学和心理方面,大流行的社会经济影响可能会影响患有糖尿病女性的长期护理,这迫切需要制定有效的政策和干预措施,以促进对这一弱势群体的最佳护理。